首页> 美国卫生研究院文献>other >Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1 SSEA-3 SSEA-4 or LeY in the preimplantation mouse embryo

【2h】

Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1 SSEA-3 SSEA-4 or LeY in the preimplantation mouse embryo

机译：在植入前的小鼠胚胎中表达阶段特异性抗原SSEA-1SSEA-3SSEA-4或LeY不需要复杂的N-聚糖或核心1衍生的O-聚糖

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

The glycan epitopes termed stage-specific embryonic antigens (SSEA) occur on glycoproteins and glycolipids in mammals. However, it is not known whether these epitopes are attached to N- or O-glycans on glycoproteins and/or on glycolipids in the developing mouse embryo. In this paper the expression of the antigens SSEA-1, SSEA-3, SSEA-4 and Le^Y was examined on ovulated eggs, early embryos and blastocysts lacking either complex and hybrid N-glycans or core-1 derived O-glycans. In all cases, antigen expression determined by fluorescence microscopy of bound monoclonal antibodies to embryos at the stage of development of maximal expression, was similar in mutant and control embryos. Thus, none of these developmental antigens are expressed solely on either complex N- or core 1-derived O-glycans attached to glycoproteins in the preimplantation mouse embryo. Furthermore, neither of these classes of glycan is essential for the expression of SSEA-1, SSEA-3, SSEA-4 or Le^Y on mouse embryos.

机译：被称为阶段特异性胚胎抗原（SSEA）的聚糖表位出现在哺乳动物的糖蛋白和糖脂上。但是，尚不清楚这些表位是否与发育中的小鼠胚胎中糖蛋白和/或糖脂上的N-或O-聚糖连接。在本文中，研究了在没有复杂和杂种N-聚糖或核心蛋白的排卵卵，早期胚胎和胚泡中，SSEA-1，SSEA-3，SSEA-4和Le ^{Y 抗原的表达。 1个衍生的O-聚糖。在所有情况下，在突变表达和对照胚胎中，在最大表达发育阶段通过与胚胎结合的单克隆抗体的荧光显微镜检查确定的抗原表达均相似。因此，这些发育抗原中没有一个仅在植入前小鼠胚胎中与糖蛋白连接的复合N或核心1衍生的O-聚糖上单独表达。此外，这两种聚糖都不是在小鼠胚胎上表达SSEA-1，SSEA-3，SSEA-4或Le ^{Y 所必需的。}}

著录项

期刊名称 other
作者
Suzannah A Williams; Pamela Stanley;
展开▼
作者单位

展开▼
年(卷),期 -1(26),3
年度 -1
页码 335–347
总页数 19
原文格式 PDF
正文语种
中图分类
关键词
N-glycans O-glycans Mgat1 T-synthase preimplantation mouse embryos SSEA immunofluorescence microscopy;

机译：N-聚糖;O-聚糖;Mgat1;T-合酶;植入前小鼠胚胎;SSEA;免疫荧光显微镜;

相似文献

外文文献
中文文献

1. Ywhaz和ATPase6在小鼠植入前胚胎中阶段特异性表达的分析 [J] . 李文雍, 梁前进, 等发育与生殖生物学报：英文版 . 2002,第004期
2. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo [J] . Williams SA, Stanley P Glycoconjugate journal . 2009,第3期

机译：在植入前的小鼠胚胎中表达阶段特异性抗原SSEA-1，SSEA-3，SSEA-4或Le（Y）不需要复杂的N-聚糖或核心1衍生的O-聚糖
3. Complex N -glycans or core 1-derived O -glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or LeY in the preimplantation mouse embryo [J] . Suzannah A. Williams, Pamela Stanley Glycoconjugate Journal . 2009,第3期

机译：在植入前的小鼠胚胎中表达阶段特异性抗原SSEA-1，SSEA-3，SSEA-4或Le Y 不需要复杂的N-聚糖或核心1衍生的O-聚糖
4. Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage [J] . Ban Sato, Yohko U Katagiri, Kenji Miyado, BMC Developmental Biology . 2011,第1期

机译：富含带有阶段特异性胚胎抗原4表位的monosialylGb5Cer的脂质筏参与卵裂期小鼠植入前胚胎的发育
5. The expression of reference genes affecting preimplantation mouse embryo death in the DDK syndrome [C] . Gendi Song, Baoguo Chai, Chunli Li, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：影响DDK综合征植入前小鼠胚胎死亡的参考基因的表达
6. Gene expression during preimplantation development in the mouse embryo. [D] . Zeng, Fanyi. 2005

机译：小鼠胚胎着床前发育过程中的基因表达。
7. Premature Ovarian Failure in Mice with Oocytes Lacking Core 1-Derived O-Glycans and Complex N-Glycans [O] . Suzannah A. Williams, Pamela Stanley -1

机译：缺少核心1衍生的O-聚糖和复杂的N-聚糖的卵母细胞小鼠卵巢早衰。
8. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. [O] . Williams, SA, Stanley, P 2009

机译：在植入前的小鼠胚胎中表达阶段特异性抗原SSEA-1，SSEA-3，SSEA-4或Le（Y）不需要复杂的N-聚糖或核心1衍生的O-聚糖。

Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1 SSEA-3 SSEA-4 or LeY in the preimplantation mouse embryo

摘要

著录项

相似文献

相关主题

期刊订阅