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Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate

机译：硫胺素-噻唑在真核生物中的生物合成：噻唑互变异构体中间体的鉴定

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Thiamin thiazole biosynthesis in eukaryotes is still not completely understood. In this report, a late intermediate, tightly bound to the active site of the Saccharomyces cerevisiae thiazole synthase, was identified as an adenylated thiazole tautomer. The reactivity of this unusual compound was evaluated. Its identification provides an additional molecular snapshot of the complex reaction sequence catalyzed by the eukaryotic thiazole synthase and identifies the final step of the thiamin-thiazole biosynthesis.

机译：真核生物中硫胺噻唑的生物合成仍未完全了解。在此报告中，与啤酒酵母噻唑合酶活性位点紧密结合的晚期中间体被鉴定为腺苷酸化的噻唑互变异构体。评价该不寻常化合物的反应性。它的鉴定提供了由真核生物噻唑合酶催化的复杂反应序列的其他分子快照，并鉴定了硫胺-噻唑生物合成的最终步骤。

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期刊名称 other
作者
Abhishek Chatterjee; Frank C. Schroeder; Christopher T. Jurgenson; Steven E. Ealick; Tadhg P. Begley;
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年(卷),期 -1(130),34
年度 -1
页码 11394–11398
总页数 13
原文格式 PDF
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1. Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate [J] . Abhishek Chatterjee, Frank C. Schroeder, Christopher T. Jurgenson, Journal of the American Chemical Society . 2008,第34期

机译：硫胺素-噻唑在真核生物中的生物合成：噻唑互变异构体中间体的鉴定
2. Thiamin Biosynthesis in Eukaryotes:Characterization of the Enzyme-Bound Product of Thiazole Synthase from Saccharomyces cerevisiae and Its Implications in Thiazole Biosynthesis [J] . Abhishek Chatterjee, Christopher T.Jurgenson, Frank C.Schroeder, Journal of the American Chemical Society . 2006,第22期

机译：真核生物中的硫胺素生物合成：酿酒酵母中噻唑合酶的酶结合产物的表征及其在噻唑生物合成中的意义
3. A Missing Enzyme in Thiamin Thiazole Biosynthesis:Identification of Tenl as a Thiazole Tautomerase [J] . Amrita B. Hazra, Ying Han, Abhishek Chatterjee, Journal of the American Chemical Society . 2011,第24期

机译：硫胺素噻唑生物合成中缺少的酶：Tenl的噻唑互变异构酶的鉴定。
4. Capturing transient biosynthetic intermediates on the post-translationally modified polyketide synthase involved in the biosynthesis of lovastatin by FT-ICR-MS. [C] . Michael J. Meehan, Pieter C. Dorrestein American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过FT-ICR-MS捕获涉及洛伐他汀生物合成的翻译后改性聚酮合成酶的瞬时生物合成中间体。
5. RNA-dependent selenocysteine biosynthesis in eukaryotes and Archaea. [D] . Palioura, Sotiria. 2010

机译：真核生物和古细菌中RNA依赖的硒代半胱氨酸的生物合成。
6. Biosynthesis of the Thiamin Thiazole in Eukaryotes: The Conversion of NAD to an Advanced Intermediate [O] . Abhishek Chatterjee, Christopher T. Jurgenson, Frank C. Schroeder, -1

机译：硫胺素噻唑在真核生物中的生物合成：NAD向高级中间体的转化
7. Biosynthesis of the Thiamin Thiazole in Bacillus subtilis: Identification of the Product of the Thiazole Synthase-Catalyzed Reaction [O] . Amrita Hazra, Abhishek Chatterjee, Tadhg P. Begley 2009

机译：枯草芽孢杆菌中硫胺噻唑的生物合成：鉴定噻唑合成酶催化反应的产物

Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate

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