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Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats

机译：短暂的剥夺和再暴露间隔对选择性饲养高耗酒精大鼠的乙醇饮酒行为的影响

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Alcoholics generally display cycles of excessive ethanol intake, abstinence and relapse behavior. Using an animal model of relapse-like drinking, the alcohol deprivation effect (ADE), our laboratory has shown that repeated 2-week cycles of ethanol deprivation and re-exposure, following an initial 6 week access period, result in a robust ADE by alcohol-preferring (P) and high alcohol-drinking (HAD-1 and HAD-2) rats. These rat lines have been selectively bred to prefer a 10% ethanol solution over water. The present study examined whether P and HAD rats would display an ADE using much shorter ethanol deprivation and re-exposure intervals. Rats were given either continuous or periodic concurrent access to multiple concentrations [10%, 20%, and 30%, volume/volume (vol./vol.)] of ethanol. The periodic protocol involved access to ethanol for 12 days followed by 4 cycles of 4 days of deprivation and 4 days of re-exposure to ethanol access. HAD rats displayed a robust 24 hour ADE upon 1st re-exposure (HAD-1: ~ 5 vs. 8 g/kg/day; HAD-2: ~ 6 vs. 9 g/kg/day, baseline vs. re-exposure), whereas P rats (~ 7 vs. 8 g/kg/day) displayed a modest, nonsignificant, increase in 24 hour intake. In a separate group of rats, ethanol intake and blood alcohol concentrations (BACs) after the 1st hour of the 4th re-exposure cycle were HAD-1: 2.0 g/kg and 97 mg%, HAD-2: 2.3 g/kg and 73 mg%, and P: 1.2 g/kg and 71 mg%; with all three lines displaying a robust 1st hour ADE. These findings suggest that (a) an ADE may be observed with short ethanol deprivation and re-exposure intervals in HAD rats, and (b) the genetic make-up of the P and HAD rats influences the expression of this ADE.
机译：酗酒者通常会出现过量乙醇摄入，节制和复发行为的循环。我们的实验室使用复发样饮酒的动物模型，即酒精剥夺效应（ADE），我们发现，在最初的6周使用期后，重复2周的乙醇剥夺和再暴露循环会导致ADE的强劲表现。酒精偏爱（P）和高酒精摄入（HAD-1和HAD-2）大鼠。这些大鼠品系经过选择性繁殖，比水更喜欢使用10％的乙醇溶液。本研究检查了P和HAD大鼠是否会使用更短的乙醇剥夺和再暴露间隔来显示ADE。给大鼠连续或定期并发使用多种浓度[10％，20％和30％体积/体积（体积/体积）]的乙醇。定期方案包括获取乙醇12天，然后进行4个循环，分别是剥夺4天和重新暴露于乙醇4天。在第一次暴露后，HAD大鼠表现出稳定的24小时ADE（HAD-1：〜5 vs. 8 g / kg / day； HAD-2：〜6 vs. 9 g / kg / day每天，基线vs.再暴露），而P大鼠（〜7 vs. 8 g / kg /天）显示24小时摄入量有适度，无意义的增加。在另一组大鼠中，第4次再暴露周期的第1小时后的乙醇摄入量和血液酒精浓度（BAC）为HAD-1：2.0 g / kg和97 mg％，HAD-2：2.3 g / kg和73 mg％，P：1.2 g / kg和71 mg％；所有三行显示的是稳定的1 st 小时ADE。这些发现表明：（a）在HAD大鼠中观察到的ADE具有较短的乙醇剥夺和重新暴露间隔，并且（b）P和HAD大鼠的遗传组成影响了该ADE的表达。

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