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首页> 美国卫生研究院文献>other >In Vivo T1ρ Mapping in Cartilage Using 3D Magnetization-Prepared Angle-Modulated Partitioned k-Space Spoiled Gradient Echo Snapshots (3D MAPSS)
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In Vivo T1ρ Mapping in Cartilage Using 3D Magnetization-Prepared Angle-Modulated Partitioned k-Space Spoiled Gradient Echo Snapshots (3D MAPSS)

机译：使用3D磁化准备的角度调制分区k空间损坏的梯度回波快照在软骨中进行体内T1ρ映射（3D MAPSS）

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摘要

For T1ρ quantification, a three-dimensional (3D) acquisition is desired to obtain high-resolution images. Current 3D methods that use steady-state spoiled gradient-echo (SPGR) imaging suffer from high SAR, low signal-to-noise ratio (SNR), and the need for retrospective correction of contaminating T1 effects. In this study, a novel 3D acquisition scheme–magnetization-prepared angle-modulated partitioned-k-space SPGR snapshots (3D MAPSS)–was developed and used to obtain in vivo T1ρ maps. Transient signal evolving towards the steady-state were acquired in an interleaved segmented elliptical centric phase encoding order immediately after a T1ρ magnetization preparation sequence. RF cycling was applied to eliminate the adverse impact of longitudinal relaxation on quantitative accuracy. A variable flip angle train was designed to provide a flat signal response to eliminate the filtering effect in k-space caused by transient signal evolution. Experiments in phantoms agreed well with results from simulation. The T1ρ values were 42.4 ± 5.2 ms in overall cartilage of healthy volunteers. The average coefficient-of-variation (CV) of mean T1ρ values (N = 4) for overall cartilage was 1.6%, with regional CV ranging from 1.7% to 8.7%. The fitting errors using MAPSS were significantly lower (P < 0.05) than those using sequences without RF cycling and variable flip angles.
机译：对于T1ρ量化，需要进行三维（3D）采集以获得高分辨率图像。当前使用稳态破坏梯度回波（SPGR）成像的3D方法存在高SAR，低信噪比（SNR）以及需要追溯校正污染T1效应的问题。在这项研究中，开发了一种新颖的3D采集方案-磁化准备的角度调制分区k空间SPGR快照（3D MAPSS），并用于获取体内T1ρ图。在T1ρ磁化准备序列之后，立即以交错的分段椭圆中心相位编码顺序获取向稳态演化的瞬态信号。应用射频循环以消除纵向弛豫对定量精度的不利影响。设计了可变的翻转角列，以提供平坦的信号响应，从而消除了由瞬态信号演变引起的k空间中的滤波效应。幻影中的实验与仿真结果非常吻合。在健康志愿者的整个软骨中，T1ρ值为42.4±5.2 ms。整个软骨的平均T1ρ值（N = 4）的平均变异系数（CV）为1.6％，区域CV范围为1.7％至8.7％。使用MAPSS的拟合误差显着低于（P <0.05），而使用无RF循环和可变翻转角的序列的拟合误差。

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