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首页> 美国卫生研究院文献>other >Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)–DOTA-Type Complexes
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Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)–DOTA-Type Complexes

机译：迈向MRI造影剂的合理设计：Electro（III）–DOTA型配合物的配位几何结构在很大程度上不影响电子自旋弛豫

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Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. One of the reasons for the poor understanding of electron-spin relaxation is that it is closely related to the ligand-field parameters of the Gd3+ ion that forms the basis of MRI contrast agents and these complexes generally exhibit a structural isomerism that inherently complicates the study of electron spin relaxation. We have recently shown that two DOTA-type ligands could be synthesised that, when coordinated to Gd3+, would adopt well defined coordination geometries and are not subject to the problems of intramolecular motion of other complexes. The EPR properties of these two chelates were studied and the results examined with theory to probe their electron-spin relaxation properties.
机译：电子自旋弛豫是MRI造影剂功效的决定因素之一。在确定弛豫度的所有参数中，尤其是与复合物的结构有关，人们对其了解最少。对电子自旋弛豫的理解不充分的原因之一是，它与构成MRI造影剂基础的Gd 3 + 离子的配体场参数密切相关，通常这些复合物表现出结构上的异构现象，使电子自旋弛豫的研究固有地复杂化。我们最近发现，可以合成两个DOTA型配体，当与Gd 3 + 配位时，将采用定义明确的配位几何结构，并且不存在其他配合物的分子内运动问题。研究了这两种螯合物的EPR性质，并用理论检验了结果，以探索其电子自旋弛豫性能。

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