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Towards a functional topography of sensory gating areas: invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

机译：走向感觉门控区域的功能性地形图：癫痫手术候选者的有创P50记录和电刺激测绘

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摘要

The filtering of sensory information, also referred to as “sensory gating”, is impaired in various neuropsychiatric diseases. In the auditory domain, sensory gating is investigated mainly as a response decrease of the auditory evoked potential component P50 from one click to the second in a double click paradigm. In order to relate deficient sensory gating to anatomy, it is essential to identify the cortical structures involved in the generation of P50. However, the exact cerebral topography of P50 gating has remained largely unknown as yet. In a group of 17 patients with drug-resistant focal epilepsy, P50 was recorded invasively via subdural electrodes, and the topography of functionally indispensable (“eloquent”) cortices was obtained by electrical stimulation mapping. These eloquent areas were involved in language, motor, and sensory functions. P50 could be identified in 13 patients in either temporal (n = 8) or midfrontal sites (n = 5). There were 6 occurrences (in 5 patients) of overlap of sites with maximal P50 responses and eloquent areas. Those were auditory (n = 1), supplementary sensorimotor (n = 3), primary motor (n = 1), and supplementary negative motor (n = 1). Results suggest that the early stage of sensory gating already involves a top-down modulation of sensory input by frontal areas.
机译：在各种神经精神疾病中，感觉信息的过滤（也称为“感觉门控”）受到损害。在听觉领域，感觉门控主要是作为双击范式中听觉诱发电位分量P50从一击到第二击的反应减少而进行的。为了将不足的感觉门控与解剖学联系起来，必须确定参与P50生成的皮质结构。但是，到目前为止，P50门控的确切脑部拓扑结构仍然未知。在一组17例耐药性局灶性癫痫患者中，通过硬膜下电极侵入性记录P50，并通过电刺激绘图获得功能必不可少的（“雄辩的”）皮层的地形图。这些雄辩的领域涉及语言，运动和感觉功能。在颞部（n = 8）或额中部（n = 5）的13名患者中可以鉴定出P50。有6次（5例患者）发生P50反应最大和雄辩区域重叠的部位。这些是听觉的（n = 1），辅助感觉运动（n = 3），主运动（n = 1）和辅助负运动（n = 1）。结果表明，感觉门控的早期阶段已经涉及到额叶区域的感觉输入的自上而下的调制。

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