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Cholinergic Lesions Produce Task-Selective Effects on Delayed Matching to Position and Configural Association Learning Related to Response Pattern and Strategy

机译：胆碱能病变在延迟匹配与反应模式和策略相关的位置和构型联想学习中产生任务选择效应

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192 IgG-saporin (SAP) was used to selectively destroy cholinergic neurons in the rostral basal forebrain (e.g., medial septum (MS) and vertical limb of the diagonal band of Broca (VDB)) and/or the caudal basal forebrain (e.g., nucleus basalis magnocellularis (NBM)) of ovariectomized Sprague-Dawley rats. The effects of these lesions on two different cognitive tasks, a delayed matching to position (DMP) T-maze task, and a configural association (CA) operant conditioning task, were evaluated and compared. Injecting SAP into either the MS or NBM significantly impaired acquisition of the DMP task. Analysis showed that the effects were due largely to an affect on response patterns adopted by the rats during training, as opposed to an effect on working memory performance. Notably, the impairment in DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. Despite the deficit, most animals eventually learned the task and reached criterion; however by the end of training, controls and animals that received SAP into either the MS or NBM appeared more likely to use an allocentric place strategy to solve the task, whereas animals that received SAP into both the MS and NBM were more likely to use an egocentric response strategy. Cholinergic lesions also produced a small but significant affect on acquisition of the CA task, but only with respect to response time, and only in the SAP-NBM-treated animals. SAP-NBM lesions also produced small but significant impairments in both the number of responses and response time during the acquisition of simple associations, possibly reflecting an effect on alertness or attention. Notably, the effects on CA acquisition were small, and like the effects on DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. We conclude that selective basal forebrain cholinergic lesions produce learning deficits that are task specific, and that cholinergic denervation of either the frontal cortex or hippocampus can affect response patterns and strategy in ways that affect learning, without necessarily reflecting deficits in working memory performance.
机译：192 IgG-saporin（SAP）用于选择性破坏鸟嘴基底前脑（例如，中隔（MS）和Broca对角带的垂直肢体（VDB））和/或尾基底前脑（例如，去卵巢的Sprague-Dawley大鼠的基底基底核（NBM）。评估并比较了这些病变对两种不同的认知任务，延迟匹配位置（DMP）T迷宫任务和构型关联（CA）操作条件任务的影响。将SAP注入MS或NBM中会严重损害DMP任务的获取。分析表明，这种影响主要是由于对训练过程中大鼠采用的反应模式的影响，而不是对工作记忆性能的影响。值得注意的是，DMP采集中的损伤与海马的胆碱能神经支配程度无关。尽管有缺陷，大多数动物最终还是学会了任务并达到了标准。但是，到训练结束时，接受SAP进入MS或NBM的对照组和动物似乎更有可能使用异体放置策略来解决任务，而接受SAP进入MS和NBM的动物则更有可能使用异体放置策略。以自我为中心的应对策略。胆碱能性病变对CA任务的获得也产生了很小但重要的影响，但仅在响应时间方面，并且仅在SAP-NBM处理的动物中。在获得简单关联的过程中，SAP-NBM病变在响应数量和响应时间方面也产生了微小但显着的损伤，可能反映了对机敏性或注意力的影响。值得注意的是，对CA采集的影响很小，就像对DMP采集的影响与海马的胆碱能神经支配程度无关。我们得出的结论是，选择性基底前脑胆碱能损伤会产生特定于任务的学习障碍，额叶皮层或海马的胆碱能神经支配会以影响学习的方式影响反应模式和策略，而不必反映工作记忆表现的不足。

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