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The Pennsylvania Green Fluorophore: A Hybrid of Oregon Green and Tokyo Green for the Construction of Hydrophobic and pH-Insensitive Molecular Probes

机译：宾夕法尼亚绿色荧光团：俄勒冈绿色和东京绿色的混合体用于构建疏水性和pH不敏感的分子探针

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Fluorescent small molecules are powerful tools for exploring cellular biology. As a more hydrophobic, photostable, and less pH sensitive alternative to fluorescein, we synthesized Pennsylvania Green, a bright, monoanionic fluorophore related to Oregon Green and Tokyo Green. Comparison of membrane probes comprising N-alkyl-3 -cholesterylamine linked to 4-carboxy-Tokyo Green (pKa ~ 6.2) and 4-carboxy-Pennsylvania Green (pKa ~ 4.8)revealed that only Pennsylvania Green was highly fluorescent in acidic early and recycling endosomes within living mammalian cells.

机译：荧光小分子是探索细胞生物学的强大工具。作为荧光素的疏水性强，光稳定性好，pH敏感性较低的替代品，我们合成了宾夕法尼亚绿，一种与俄勒冈绿和东京绿有关的明亮的单阴离子荧光团。比较包含与4-羧基-东京绿（pKa〜6.2）和4-羧基-宾夕法尼亚基绿（pKa〜4.8）连接的N-烷基-3-胆固醇胺的膜探针，发现只有宾夕法尼亚州绿在酸性早期和回收利用中具有高荧光性。活哺乳动物细胞内的内体。

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Laurie Mottram; Siwarutt Boonyarattanakalin; Rebecca E. Kovel; Blake R. Peterson;
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年(卷),期 -1(8),4
年度 -1
页码 581–584
总页数 11
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1. The Pennsylvania green fluorophore: A hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes [J] . Mottram LF, Boonyarattanakalin S, Kovel RE, Organic letters . 2006,第4期

机译：宾夕法尼亚绿色荧光团：俄勒冈绿色和东京绿色的混合物，用于构建疏水性和对pH不敏感的分子探针
2. Efficient and scalable synthesis of 4-carboxy-pennsylvania green methyl ester: A hydrophobic building block for fluorescent molecular probes [J] . WoydziakZ.R., FuL., PetersonB.R. Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2014,第2期

机译：高效且可扩展地合成4-羧基-苄基钒绿色甲酯：荧光分子探针的疏水构件
3. Efficient and scalable synthesis of 4-carboxy-pennsylvania green methyl ester: A hydrophobic building block for fluorescent molecular probes [J] . WoydziakZ.R., FuL., PetersonB.R. Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2014,第2期

机译：高效且可扩展合成4羧基 - 宾夕法尼亚绿色甲酯：荧光分子探针的疏水性积木
4. Greening commonwealth of pennsylvania facilities [C] . Marcus B. Sheffer, John A. Boecker, James Toothaker The SOLAR 2000 Conference: Including Proceedings of ASES Annual Conference Proceedings of 25~(th) National Passive Solar Conference Madison, Wisconsin June 16 - 21, 2000 . 2000

机译：宾夕法尼亚州绿化设施
5. Greening construction processes using an input-output-based hybrid life cycle assessment method. [D] . Sharrard, Aurora Luscher. 2007

机译：使用基于输入-输出的混合生命周期评估方法对施工过程进行绿化。
6. Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes [O] . Zachary R. Woydziak, Liqiang Fu, Blake R. Peterson -1

机译：有效和可扩展的合成4-羧基-宾夕法尼亚绿色甲基酯：荧光分子探针的疏水构件。
7. The Pennsylvania Green Fluorophore: A Hybrid of Oregon Green and Tokyo Green for the Construction of Hydrophobic and pH-Insensitive Molecular Probes [O] . -1

机译：宾夕法尼亚绿色荧光团：俄勒冈州绿色和东京绿色的混合动力器，用于建造疏水性和pH不敏感的分子探针

The Pennsylvania Green Fluorophore: A Hybrid of Oregon Green and Tokyo Green for the Construction of Hydrophobic and pH-Insensitive Molecular Probes

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