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Islet xenografts in fully xenogeneic (rat → mouse) chimeras: Evidence for normal regulation of function in a xenogeneic mouse environment

机译：完全异种（大鼠→小鼠）嵌合体中的胰岛异种移植：在异种小鼠环境中正常调节功能的证据

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BackgroundTransplantation of untreated rat bone marrow into mouse recipients conditioned by total-body irradiation results in fully xenogeneic chimerism (rat → mouse). The chimerism is stable for up to 70 months, survival is excellent, and there is no evidence for graft-versus-host disease. We recently reported the long-term survival (> 180 days) of donor-specific pancreatic islet xenografts in these fully xenogeneic chimeras.

机译：背景将未经处理的大鼠骨髓移植到全身照射条件下的小鼠受体中会导致完全异种嵌合（大鼠→小鼠）。嵌合体在长达70个月的时间内稳定，生存期极佳，没有证据表明移植物抗宿主病。我们最近报道了在这些完全异种的嵌合体中供体特异性胰岛异种移植物的长期存活（> 180天）。

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Camillo Ricordi; Yijun Zeng; Patricia B. Carroll; Horacio L. R. Rilo; Debra R. Beretier; Thomas E. Starzl; Suzanne T. Ildstad;
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年(卷),期 -1(112),2
年度 -1
页码 327–332
总页数 10
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1. Establishment of fully xenogeneic (mouse-->rat) bone marrow chimeras: evidence for normal development and clonal deletion of mouse T cells. [J] . Mohiuddin MM, Ildstad ST, DiSesa VJ Transplantation: Official Journal of the Transplantation Society . 2000,第5期

机译：建立完全异种（小鼠->大鼠）骨髓嵌合体：小鼠T细胞正常发育和克隆缺失的证据。
2. Cross-species transplantation tolerance: rat bone marrow-derived cells can contribute to the ligand for negative selection of mouse T cell receptor V beta in chimeras tolerant to xenogeneic antigens (mouse + rat----mouse). [J] . S T Ildstad, M S Vacchio, P M Markus, The Journal of Experomental Medicine . 1992,第1期

机译：交叉物种移植耐受性：大鼠骨髓衍生的细胞可以有助于对嵌合体耐受异种抗原（小鼠+大鼠----小鼠）的小鼠T细胞受体Vβ在嵌合体中的阴小细胞受体Vβ的负选择的配体。
3. Cross-species bone marrow transplantation: evidence for tolerance induction, stem cell engraftment, and maturation of T lymphocytes in a xenogeneic stromal environment (rat----mouse). [J] . S T Ildstad, S M Wren, S S Boggs, The Journal of Experomental Medicine . 1991,第2期

机译：跨物种骨髓移植：在异种基质环境（大鼠----小鼠）中耐受诱导，干细胞移植和T淋巴细胞成熟的证据。
4. Xenogeneic hepatic chimera in a human-to-mouse model: human fetal derived-Flk1+CD31-CD34- pluripotent stem cells for immunotolerance induction [C] . Lianming Liao, Baijun Fang, Mingxia Shi, The 2nd World Congress for Chinese Biomedical Engineers . 2004

机译：人-鼠模型中的异种肝嵌合体：人胎儿来源的-Flk1 + CD31-CD34-多能干细胞用于免疫耐受诱导
5. Tumor-specific human primary T cells engineered to overexpress IL-2, IL-7, IL-15, or IL-21 confer varying degrees of tumor rejection and xenogeneic graft-versus-host disease in an immunodeficient mouse model. [D] . Markley, John Charles. 2009

机译：经过工程改造以过度表达IL-2，IL-7，IL-15或IL-21的肿瘤特异性人类原代T细胞可在免疫缺陷小鼠模型中赋予不同程度的肿瘤排斥反应和异种移植物抗宿主病。
6. LONG-TERM SURVIVAL OF DONOR-SPECIFIC PANCREATIC ISLET XENOGRAFTS IN FULLY XENOGENEIC CHIMERAS (WF RAT → B10 MOUSE) [O] . Yijun Zeng, Camillo Ricordi, Andreas Tzakis, -1

机译：完全异种嵌合体（WF大鼠→B10小鼠）特定胰腺胰岛异种移植物的长期存活
7. Islet xenografts in fully xenogeneic(Rat --> mouse) chimeras: evidence for normal regulation of function in a xenogeneic mouse environment [O] . Ricordi C, Zeng Y, Carroll PB, 1992

机译：完全异种（大鼠->小鼠）嵌合体中的胰岛异种移植物：在异种小鼠环境中正常调节功能的证据
8. Characteristics of a Xenogeneic Lymphocyte Transfer Reaction: Its Use in the Study of Graft versus Host Capability of Mouse Lymphoid Cells from Various Anatomic Sites. [R] . Catanzaro, P. J., Graham, R. C., Powell, A. E., 1976

机译：异种淋巴细胞转移反应的特征：其用于研究来自不同解剖位点的小鼠淋巴细胞的移植物抗宿主能力。

Islet xenografts in fully xenogeneic (rat → mouse) chimeras: Evidence for normal regulation of function in a xenogeneic mouse environment

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