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首页> 美国卫生研究院文献>Acta Bio Medica : Atenei Parmensis >Evaluation of the antimicrobial activity of novel composite plastics containing two silver (I) additives acyl pyrazolonate and acyl pyrazolone
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Evaluation of the antimicrobial activity of novel composite plastics containing two silver (I) additives acyl pyrazolonate and acyl pyrazolone

机译：含两种吡咯烷酮酸银和吡唑啉酮银（I）添加剂的新型复合塑料的抗菌活性评估

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摘要

Public health systems today face the dual challenges of controlling infections and curbing the increase in antimicrobial resistance manifested in drug-resistant microorganisms in hospitals and elsewhere. In the last ten years, research has been conducted to develop new materials with antimicrobial properties to be used in medical devices, increasingly found to harbour critical nosocomial infections. Two next-generation composites using the antimicrobial qualities of silver were tested against , and with the purpose of evaluating their antimicrobial and antifungal activity. These tests applied the standardized method according to ISO-2216: Plastics-Measurement of Antibacterial Activity on Plastics Surfaces. Testing was carried out using polyethylene (PE) enriched with AgNO as a positive control and PE as a negative control. The antimicrobial activity of the composites proved to be between medium (bacteriostatic) and very good (bactericidal). In particular, PE2 showed the highest scores against all microorganisms, with values ranging from good to very good. Instead, PE1 had lower scores, with a value of medium for and slight for . Statistical analysis carried out with the t-test for unpaired data showed a statistically significant difference between the positive control and the other polymers (p< .0001). Based on our findings, we conclude that the test, conducted to ISO-2216 standards, could be extended to include fungal strains and that the new composites could be used to produce antimicrobial surfaces for medical devices, for example, intubation tubes, urinary catheters, vascular prostheses, and mechanical heart valves. This would reduce the risk of microbial contamination and biofilm formation, ensuring better health outcomes for patients treated with these devices. Further testing should be done to evaluate potential future applications of these composites and the possibility of adding fungal strains to the IS0-2216 standard. ( )
机译：今天的公共卫生系统面临着控制感染和遏制医院和其他地方的耐药微生物所表现出的抗药性增加的双重挑战。在过去的十年中，已经进行了研究以开发具有抗微生物特性的新材料，这些新材料将用于医疗设备，并且越来越多地发现这些材料具有关键的医院感染。测试了两种使用银的抗菌特性的下一代复合材料，目的是评估其抗菌和抗真菌活性。这些测试采用了根据ISO-2216：塑料-塑料表面抗菌活性的测量方法的标准化方法。使用富含AgNO的聚乙烯（PE）作为阳性对照，使用PE作为阴性对照进行测试。复合材料的抗菌活性被证明介于中等（抑菌）和非常好（杀菌）之间。尤其是，PE2对所有微生物的得分最高，范围从良好到非常好。取而代之的是，PE1的得分较低，其中的值为，中等值为。使用t检验对未配对数据进行的统计分析表明，阳性对照与其他聚合物之间存在统计学上的显着差异（p <.0001）。根据我们的发现，我们得出的结论是，按照ISO-2216标准进行的测试可以扩展到包括真菌菌株，并且新的复合材料可以用于生产医疗器械（例如，插管，导尿管，人工血管和机械心脏瓣膜。这将减少微生物污染和生物膜形成的风险，从而确保使用这些设备治疗的患者获得更好的健康结果。应该进行进一步的测试，以评估这些复合材料的潜在未来应用以及将真菌菌株添加到IS0-2216标准中的可能性。 （）

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