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首页> 美国卫生研究院文献>Advances in Nutrition >Associations between Dietary Pulses Alone or with Other Legumes and Cardiometabolic Disease Outcomes: An Umbrella Review and Updated Systematic Review and Meta-analysis of Prospective Cohort Studies
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Associations between Dietary Pulses Alone or with Other Legumes and Cardiometabolic Disease Outcomes: An Umbrella Review and Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

机译：单独或与其他豆类的饮食脉冲之间的关联和心脏代谢疾病的结果：一项伞研究和更新的系统研究以及前瞻性队列研究的荟萃分析

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To update the European Association for the Study of Diabetes clinical practice guidelines for nutrition therapy, we conducted an umbrella review and updated systematic review and meta-analysis (SRMA) of prospective cohort studies of the association between dietary pulses with or without other legumes and cardiometabolic disease outcomes. We searched the PubMed, MEDLINE, EMBASE, and Cochrane databases through March 2019. We included the most recent SRMAs of prospective cohort studies and new prospective cohort studies published after the census dates of the included SRMAs assessing the relation between dietary pulses with or without other legumes and incidence and mortality of cardiovascular diseases (CVDs) [including coronary heart disease (CHD), myocardial infarction (MI), and stroke], diabetes, hypertension, and/or obesity. Two independent reviewers extracted data and assessed risk of bias. Risk estimates were pooled using the generic inverse variance method and expressed as risk ratios (RRs) with 95% CIs. The overall certainty of the evidence was assessed using the GRADE approach. Six SRMAs were identified and updated to include 28 unique prospective cohort studies with the following number of cases for each outcome: CVD incidence, 10,261; CVD mortality, 16,168; CHD incidence, 7786; CHD mortality, 3331; MI incidence, 2585; stroke incidence, 8570; stroke mortality, 2384; diabetes incidence, 10,457; hypertension incidence, 83,284; obesity incidence, 8125. Comparing the highest with the lowest level of intake, dietary pulses with or without other legumes were associated with significant decreases in CVD (RR: 0.92; 95% CI: 0.85, 0.99), CHD (RR: 0.90; 95% CI: 0.83, 0.99), hypertension (RR: 0.91; 95% CI: 0.86, 0.97), and obesity (RR: 0.87; 95% CI: 0.81, 0.94) incidence. There was no association with MI, stroke, and diabetes incidence or CVD, CHD, and stroke mortality. The overall certainty of the evidence was graded as “low” for CVD incidence and “very low” for all other outcomes. Current evidence shows that dietary pulses with or without other legumes are associated with reduced CVD incidence with low certainty and reduced CHD, hypertension, and obesity incidence with very low certainty. More research is needed to improve our estimates. This trial was registered at clinicaltrials.gov as .
机译：为了更新欧洲糖尿病研究协会营养治疗临床实践指南，我们对前瞻性队列研究进行了总括性审查，并更新了系统性回顾和荟萃分析（SRMA），该队列研究了饮食脉冲与有无其他豆类和心脏代谢之间的关系。疾病结果。我们搜索了截至2019年3月的PubMed，MEDLINE，EMBASE和Cochrane数据库。我们纳入了前瞻性队列研究的最新SRMA，并在包括SRMA的普查日期之后发布了新的前瞻性队列研究，评估了有无其他饮食脉冲之间的关系。豆类以及心血管疾病（CVD）[包括冠心病（CHD），心肌梗塞（MI）和中风]，糖尿病，高血压和/或肥胖的发生率和死亡率。两名独立审稿人提取了数据并评估了偏见风险。使用通用逆方差方法汇总风险估计，并表示为具有95％CI的风险比（RRs）。使用GRADE方法评估证据的整体确定性。确定并更新了六个SRMA，包括28项独特的前瞻性队列研究，每种结局的病例数如下：CVD发生率为10,261； CVD死亡率16,168；冠心病发病率7786;冠心病死亡率3331; MI发生率2585；中风发生率8570;中风死亡率，2384；糖尿病发病率10,457;高血压发病率83,284；肥胖发生率，8125。将最高摄入量与最低摄入量进行比较，有或没有其他豆类的饮食脉冲与CVD（RR：0.92; 95％CI：0.85，0.99），CHD（RR：0.90; 95）的显着降低有关。 ％CI：0.83，0.99），高血压（RR：0.91； 95％CI：0.86，0.97）和肥胖（RR：0.87； 95％CI：0.81、0.94）发生率。与心肌梗死，中风和糖尿病的发病率，CVD，CHD和中风的死亡率没有关系。证据的总体确定性对于CVD的发生被评为“低”，对于所有其他结果被评为“非常低”。目前的证据表明，有或没有其他豆类的饮食脉冲与降低心血管疾病的发生率（降低确定性）和降低冠心病，高血压和肥胖症的发生率（降低确定性）有关。需要更多的研究来改善我们的估计。该试验已在Clinicaltrials.gov上注册为。

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