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首页> 美国卫生研究院文献>Aging (Albany NY) >Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria
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Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria

机译：将微生物群从长寿人移植到小鼠可减少与衰老相关的指数并转移有益细菌

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A close relationship between age and gut microbiota exists in invertebrates and vertebrates, including humans. Long-living people are a model for studying healthy aging; they also have a distinctive microbiota structure. The relationship between the microbiota of long-living people and aging phenotype remains largely unknown. Herein, the feces of long-living people were transplanted into mice, which were then examined for aging-related indices and beneficial bacteria. Mice transplanted with fecal matter from long-living people (L group) had greater α diversity, more probiotic genera ( and ), and short-chain fatty acid producing genera ( ) than the control group. L group mice also accumulated less lipofuscin and β-galactosidase and had longer intestinal villi. This study indicates the effects that the gut microbiota from long-living people have on healthy aging.
机译：无脊椎动物和脊椎动物，包括人类，年龄与肠道菌群之间存在密切关系。长寿的人是研究健康衰老的典范；它们还具有独特的微生物群结构。长寿人群的微生物群与衰老表型之间的关系仍然未知。在此，将长寿人的粪便移植到小鼠中，然后检查其衰老相关指标和有益细菌。与对照组相比，从长寿人（L组）移植粪便的小鼠具有更大的α多样性，更多的益生菌属（和）和产生短链脂肪酸的属（）。 L组小鼠也积累了较少的脂褐素和β-半乳糖苷酶，并具有更长的肠绒毛。这项研究表明了长寿人的肠道菌群对健康衰老的影响。

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