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Note: Assessment of Spontaneous Fluctuations of Viral Load in Untreated Patients with Chronic Hepatitis C by Two Standardized Quantitation Methods: Branched DNA and Amplicor Monitor

机译：注意：通过两种标准化的定量方法：分支DNA和Amplicor监测仪评估未治疗的丙型肝炎患者病毒载量的自发波动

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Quantitation of hepatitis C virus (HCV) RNA in serum has been used to predict and monitor the efficacy of interferon therapy in chronic HCV infection. We prospectively studied the fluctuation of viremia by a longitudinal follow-up of HCV RNA levels for 2 months in six untreated patients. Spontaneous fluctuations of HCV RNA ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9- to 5.6-fold with Monitor. These large spontaneous fluctuations (up to 0.75 log), observed daily, weekly, and monthly, raise doubt about the clinical value of a single assessment of pretherapeutic viremia.

机译：血清丙型肝炎病毒（HCV）RNA的定量已用于预测和监测干扰素治疗慢性HCV感染的功效。我们通过对6名未经治疗的患者进行了2个月的HCV RNA水平的纵向随访，对病毒血症的波动进行了前瞻性研究。 HCV RNA的自发波动在分支DNA检测中为2.8-5.7倍，在Monitor中为2.9-5.6倍。每天，每周和每月观察到的这些较大的自发波动（高达0.75 log），使人们对治疗前病毒血症的单次评估的临床价值产生怀疑。

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期刊名称 Journal of Clinical Microbiology
作者
Philippe Halfon; Marc Bourlière; Gilles Halimi; Hacène Khiri; Patrice Bertezene; Isabelle Portal; Danielle Botta-Fridlund; André Pierre Gauthier; Monique Jullien; Jean Marc Feryn; Victoria Gerolami; Guy Cartouzou;
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年(卷),期 1998(36),7
年度 1998
页码 2073–2075
总页数 3
原文格式 PDF
正文语种
中图分类微生物学;
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1. Assessment of Spontaneous Fluctuations of Viral Load in Untreated Patients with Chronic Hepatitis C by Two Standardized Quantitation Methods: Branched DNA and Amplicor Monitor [J] . Philippe Halfon, Marc Bourlière, Gilles Halimi, Journal of Clinical Microbiology . 1998,第7期

机译：通过两种标准化的定量方法：分支DNA和Amplicor监测仪评估未治疗的丙型肝炎患者病毒载量的自发波动
2. Assessment of Viral Loads in Patients with Chronic Hepatitis C with AMPLICOR HCV MONITOR Version 1.0, COBAS HCV MONITOR Version 2.0, and QUANTIPLEX HCV RNA Version 2.0 Assays [J] . Michéle Martinot-Peignoux, Véronique Le Breton, Sandrine Fritsch, Journal of Clinical Microbiology . 2000,第7期

机译：使用AMPLICOR HCV MONITOR 1.0版，COBAS HCV MONITOR 2.0版和QUANTIPLEX HCV RNA 2.0版方法评估慢性丙型肝炎患者的病毒载量
3. Comparative Evaluation of the Total Hepatitis C Virus Core Antigen, Branched-DNA, and Amplicor Monitor Assays in Determining Viremia for Patients with Chronic Hepatitis C during Interferon Plus Ribavirin Combination Therapy [J] . Pascal Veillon, Christopher Payan, Gastón Picchio, Journal of Clinical Microbiology . 2003,第7期

机译：丙型肝炎病毒核心抗原，支链DNA和Amplicor监测试剂盒测定慢性丙型肝炎患者在干扰素加利巴韦林联合治疗期间的病毒血症的比较评价
4. Nonlinear Mixed Effects Modelling Viral Load in Untreated Patients with Chronic Hepatitis C [C] . Jian Huang, Kathleen OSullivan, Elizabeth Kenny-Walsh, The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：非线性混合效应模拟慢性丙型肝炎未经治疗的患者的病毒载量
5. Assessment of Viral Suppression by Various Retention in Care Measures and Viral Load Monitoring Patterns among a Cohort of HIV-Infected Patients in Washington, DC. [D] . Kalmin, Mariah Mattera. 2017

机译：在华盛顿特区的一组HIV感染患者中，通过各种保留护理措施和病毒载量监测模式来评估病毒抑制。
6. Assessment of Viral Loads in Patients with Chronic Hepatitis C with AMPLICOR HCV MONITOR Version 1.0 COBAS HCV MONITOR Version 2.0 and QUANTIPLEX HCV RNA Version 2.0 Assays [O] . Michéle Martinot-Peignoux, Véronique Le Breton, Sandrine Fritsch, 2000

机译：使用AMPLICOR HCV MONITOR 1.0版COBAS HCV MONITOR 2.0版和QUANTIPLEX HCV RNA 2.0版方法评估慢性丙型肝炎患者的病毒载量
7. Assessment of Viral Loads in Patients with Chronic Hepatitis C with AMPLICOR HCV MONITOR Version 1.0, COBAS HCV MONITOR Version 2.0, and QUANTIPLEX HCV RNA Version 2.0 Assays [O] . Michéle Martinot-Peignoux, Véronique Le Breton, Sandrine Fritsch, 2000

机译：慢性丙型肝炎患者的病毒载荷评估慢性丙型肝炎患者1.0版，COBAS HCV监测器版本2.0和Quantiplex HCV RNA版本2.0测定

Note: Assessment of Spontaneous Fluctuations of Viral Load in Untreated Patients with Chronic Hepatitis C by Two Standardized Quantitation Methods: Branched DNA and Amplicor Monitor

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