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首页> 美国卫生研究院文献>Antioxidants >Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15
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Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15

机译：利用链霉菌属生物活性材料开发多功能美容霜。具有合成介孔二氧化硅颗粒SBA-15的T65

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Various cosmetics having a single function are increasingly being used, but cosmetics having multifunctional activities remain limited. We aimed to develop a multifunctional cosmetic cream having antioxidant, anti-tyrosinase, anti-aging and antimicrobial activities. Antimicrobial activities were performed by disc-diffusion method. Cell toxicity and cell proliferations were evaluated in a 96-well plate with different cell lines such as HaCaT, RAW264.7, CCD-986Sk, B16F1, and B16F10. Mushroom tyrosinase inhibition, elastase inhibition, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities were evaluated and IC was calculated. Mesoporous silica particle was synthesized using Pluronic P123 and tetraethyl ortho-silicate (TEOS). Facial pictures were captured by VISIA-CR (Facial Imaging System for Clinical Research). Roughness of image was analysed by PRIMOS software and brightness of image was analyzed by Chromameter CR-400. The crude product of strain T65 inhibited the different human pathogenic bacteria such as , , , , , and . The IC of T65 crude product for mushroom tyrosinase, elastase, and DPPH radical scavenging activities were 58.73, 14.68, and 6.31 µg/mL, respectively. T65 crude product proliferated collagen type I in CCD-986Sk cell up to 145.91% ± 9.11% (mean ± SD; mean of 24, 48, and 72 h) at 250 pg/mL. Synthesized mesoporous particles (SBA-15) confirmed the sustainable performance by control-release for three days. Formulated functional cosmetic cream containing T65 embedded SBA-15, significantly decreased the skin roughness by 4.670% and increased the skin brightness by 0.472% after application of 4 weeks. T65 crude product inhibited both Gram-positive and Gram-negative pathogens. Synthesized mesoporous particle, SBA-15, confirmed the physiologically active substance was released in sustainable release condition. T65 crude product showed impeccable antimicrobial, antioxidant, anti-aging, and whitening activities with non-cytotoxic effects to different cell lines related to the human skin.
机译：越来越多地使用具有单一功能的各种化妆品，但是具有多功能活性的化妆品仍然受到限制。我们旨在开发一种具有抗氧化，抗酪氨酸酶，抗衰老和抗菌活性的多功能美容霜。通过圆盘扩散法进行抗菌活性。在具有不同细胞系（例如HaCaT，RAW264.7，CCD-986Sk，B16F1和B16F10）的96孔板中评估细胞毒性和细胞增殖。评估了蘑菇酪氨酸酶抑制，弹性蛋白酶抑制和1,1-二苯基-2-吡啶并肼基（DPPH）自由基清除活性，并计算了IC。使用Pluronic P123和原硅酸四乙酯（TEOS）合成了介孔二氧化硅颗粒。通过VISIA-CR（用于临床研究的面部成像系统）捕获面部图片。用PRIMOS软件分析图像的粗糙度，用色度计CR-400分析图像的亮度。 T65菌株的粗产物抑制了人类的各种病原菌，如，，，，，和。 T65粗产物对蘑菇酪氨酸酶，弹性蛋白酶和DPPH自由基清除活性的IC分别为58.73、14.68和6.31 µg / mL。在pg / mL浓度为250 pg / mL时，T65粗产物在CCD-986Sk细胞中增殖了I型胶原，增至145.91％±9.11％（平均值±SD; 24、48和72小时的平均值）。合成的中孔颗粒（SBA-15）通过控制释放三天证实了其可持续的性能。配制的含有T65嵌入SBA-15的功能性美容霜，使用4周后，皮肤粗糙度显着降低了4.670％，皮肤亮度提高了0.472％。 T65粗产物同时抑制革兰氏阳性和革兰氏阴性病原体。合成的中孔颗粒SBA-15证实了生理活性物质是在可持续释放条件下释放的。 T65粗产物显示出无可挑剔的抗微生物，抗氧化剂，抗衰老和美白活性，对与人类皮肤相关的不同细胞系均无细胞毒性作用。

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