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首页> 美国卫生研究院文献>Antibiotics >Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?
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Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?

机译：噬菌体-抗生素联合治疗：抗生素对噬菌体疗法的药效学有拮抗作用吗？

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Bacteria can evolve resistance to antibiotics. Even without changing genetically, bacteria also can display tolerance to antibiotic treatments. Many antibiotics are also broadly acting, as can result in excessive modifications of body microbiomes. Particularly for antibiotics of last resort or in treating extremely ill patients, antibiotics furthermore can display excessive toxicities. Antibiotics nevertheless remain the standard of care for bacterial infections, and rightly so given their long track records of both antibacterial efficacy and infrequency of severe side effects. Antibiotics do not successfully cure all treated bacterial infections, however, thereby providing a utility to alternative antibacterial approaches. One such approach is the use of bacteriophages, the viruses of bacteria. This nearly 100-year-old bactericidal, anti-infection technology can be effective against antibiotic-resistant or -tolerant bacteria, including bacterial biofilms and persister cells. Ideally phages could be used in combination with standard antibiotics while retaining their anti-bacterial pharmacodynamic activity, this despite antibiotics interfering with aspects of bacterial metabolism that are also required for full phage infection activity. Here I examine the literature of pre-clinical phage-antibiotic combination treatments, with emphasis on antibiotic-susceptible bacterial targets. I review evidence of antibiotic interference with phage infection activity along with its converse: phage antibacterial functioning despite antibiotic presence.
机译：细菌可以产生对抗生素的抗性。即使没有遗传改变，细菌也可以表现出对抗生素治疗的耐受性。许多抗生素的作用也很广泛，因为它们可能导致人体微生物组的过度修饰。特别是对于最后使用的抗生素或在治疗重症患者中，抗生素还会显示出过度的毒性。尽管如此，抗生素仍然是细菌感染的标准治疗方法，而且鉴于其在抗菌功效和严重副作用频发方面的悠久历史，这是正确的。然而，抗生素不能成功治愈所有治疗的细菌感染，从而为替代的抗菌方法提供了实用工具。一种这样的方法是使用噬菌体，即细菌的病毒。这项具有近100年历史的杀菌，抗感染技术可以有效抵抗抗生素耐药性或耐受性细菌，包括细菌生物膜和持久性细胞。理想情况下，噬菌体可以与标准抗生素结合使用，同时保留其抗菌药效学活性，尽管抗生素会干扰细菌代谢的各个方面，这也是完整噬菌体感染活性所必需的。在这里，我回顾了临床前噬菌体-抗生素联合治疗的文献，重点是对抗生素敏感的细菌靶标。我回顾了抗生素对噬菌体感染活性的干扰及其相反的证据：尽管存在抗生素，噬菌体的抗菌功能仍然存在。

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