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首页> 美国卫生研究院文献>Beilstein Journal of Nanotechnology >Facile biogenic fabrication of hydroxyapatite nanorods using cuttlefish bone and their bactericidal and biocompatibility study
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Facile biogenic fabrication of hydroxyapatite nanorods using cuttlefish bone and their bactericidal and biocompatibility study

机译：墨鱼骨方便地制备羟基磷灰石纳米棒及其杀菌和生物相容性研究

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Cuttlefish bones are an inexpensive source of calcium carbonate, which are produced in large amounts by the marine food industry, leading to environmental contamination and waste. The nontoxicity, worldwide availability and low production cost of cuttlefish bone products makes them an excellent calcium carbonate precursor for the fabrication of hydroxyapatite. In the present study, a novel oil-bath-mediated precipitation method was introduced for the synthesis of hydroxyapatite (Hap) nanorods using cuttlefish bone powder as a precursor (CB-Hap NRs). The obtained CB-Hap NRs were investigated using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) techniques to evaluate their physicochemical properties. The crystallite size (20.86 nm) obtained from XRD data and the elemental analysis (Ca/P molar ratio was estimated to be 1.6) showed that the Hap NRs are similar to that of natural human bone (≈1.67). Moreover, the FTIR data confirmed the presence of phosphate as a functional group and the TGA data revealed the thermal stability of Hap NRs. In addition, the antibacterial study showed a significant inhibitory effect of CB-Hap NRs against (zone of inhibition – 14.5 ± 0.5 mm) and (13 ± 0.5 mm), whereas the blood compatibility test showed that the CB-Hap NRs exhibited a concentration-mediated hemolytic effect. These biogenic CB-Hap NRs with improved physicochemical properties, blood compatibility and antibacterial efficacy could be highly beneficial for orthopedic applications in the future.
机译：墨鱼骨头是碳酸钙的廉价来源，碳酸钙由海洋食品工业大量生产，导致环境污染和浪费。墨鱼骨制品的无毒，可在全球范围内使用以及较低的生产成本使其成为制造羟基磷灰石的出色碳酸钙前体。在本研究中，介绍了一种新颖的油浴介导的沉淀方法，以墨鱼骨粉为前体（CB-Hap NRs）来合成羟基磷灰石（Hap）纳米棒。使用透射电子显微镜（TEM），傅立叶变换红外光谱（FTIR），X射线衍射（XRD）和热重分析（TGA）技术研究获得的CB-Hap NRs，以评估其理化性质。从XRD数据和元素分析（Ca / P摩尔比估计为1.6）获得的微晶尺寸（20.86 nm）表明，Hap NR与天然人骨的相似（≈1.67）。此外，FTIR数据证实了磷酸盐作为官能团的存在，TGA数据表明了Hap NRs的热稳定性。此外，抗菌研究显示CB-Hap NRs对（抑制区– 14.5±0.5 mm）和（13±0.5 mm）有明显的抑制作用，而血液相容性测试表明CB-Hap NRs表现出一定浓度。介导的溶血作用。这些具有改善的理化特性，血液相容性和抗菌功效的生物型CB-Hap NR可能在将来对整形外科应用非常有益。

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