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首页> 美国卫生研究院文献>Bioactive Materials >Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility
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Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility

机译：在镁合金支架材料上逐层沉积生物活性层以提高耐腐蚀性和生物相容性

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Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability. However, the rapid degradation rate and the insufficient biocompatibility restrict its clinical applications. In this study, the magnesium alloy (AZ31B) was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid, followed by the immobilization of chitosan-functionalized graphene oxide (GOCS). Heparin (Hep) and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer (LBL) to construct the GOCS/Hep bioactive multilayer coating, and the corrosion resistance and biocompatibility were extensively explored. The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent corrosion resistance. The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation, resulting in an excellent blood compatibility. In addition, the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells, but also promote the vascular endothelial growth factor (VEGF) and nitric oxide (NO) expression of the attached endothelial cells on the surfaces. Therefore, the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys, which is expected to promote the application of magnesium alloys in biomaterials or medical devices, especially cardiovascular stent.
机译：镁合金由于其良好的机械性能和可生物降解性，被认为是理想的心血管支架材料之一。然而，快速的降解速率和不足的生物相容性限制了其临床应用。在这项研究中，镁合金（AZ31B）通过结合表面化学处理和16-膦酰基-十六烷酸的原位自组装，然后固定化壳聚糖功能化的氧化石墨烯（GOCS）进行了改性。将肝素（Hep）和GOCS交替地逐层固定在GOCS改性的表面上，以构建GOCS / Hep生物活性多层涂层，并广泛探索了耐腐蚀性和生物相容性。结果表明，GOCS / Hep生物活性多层涂层可以赋予镁合金优异的耐蚀性。 GOCS / Hep多层涂层可显着降低溶血速率以及血小板的粘附和活化，从而具有出色的血液相容性。另外，多层涂层不仅可以增强内皮细胞的粘附和增殖，而且可以促进表面上附着的内皮细胞的血管内皮生长因子（VEGF）和一氧化氮（NO）表达。因此，本研究方法可用于同时控制镁合金的耐蚀性和提高其生物相容性，有望促进镁合金在生物材料或医疗器械，尤其是心血管支架中的应用。

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