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ElTetrado: a tool for identification and classification of tetrads and quadruplexes

机译:ElTetrado:用于对四线和四线体进行识别和分类的工具

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摘要

One of the key problems that can be solved by structural bioinformatics is the discovery and analysis of motifs that form in molecular structures. Recurring patterns are searched for at all levels of the architecture: in sequence, secondary and tertiary structure [ – ]. Motif’s discovery entails the research into its influence on the molecule functions. Among the motifs that are currently being researched in many areas of life sciences are quadruplexes. These structures were first found in DNA, in the late 1960s. However, only after their association with targeted therapies against cancer and neurodegenerative diseases, the study on these motifs started to expand [ ]. Today, computationally-supported analysis of quadruplex characteristics constitutes a relatively new challenge in structural bioinformatics and computational biology [ , ].
机译:结构生物信息学可以解决的关键问题之一是发现和分析分子结构中形成的基序。在架构的所有级别上搜索重复模式:依次,二级和三级结构[–]。 Motif的发现需要对其分子功能的影响进行研究。四联体是目前在生命科学许多领域中研究的主题。这些结构最早是在1960年代后期的DNA中发现的。然而,只有在将它们与针对癌症和神经退行性疾病的靶向疗法相关联之后,对这些基序的研究才开始扩展[]。如今,四重特征的计算支持分析在结构生物信息学和计算生物学中构成了一个相对较新的挑战[,]。

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