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首页> 美国卫生研究院文献>BMC Genomics >Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information
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Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information

机译：通过逐点相互信息从成对的RNA-seq数据集中构建竞争性内源RNA网络

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摘要

Long non-coding RNAs (lncRNAs) are involved in a variety of biological functions [ ]. However, not much is known about the functions and regulatory mechanisms of non-coding RNAs with other types of RNAs [ ]. Some early studies [ , ] found that a RNA can influence the expression level of other RNAs by competing to bind to the same miRNA. Based on these early findings, Pandolfi proposed a competing endogenous RNA (ceRNA) hypothesis [ ]. This ceRNA hypothesis stated that non-coding RNAs and coding RNAs would widely compete with mRNAs for binding to the same miRNAs. This ceRNA hypothesis not only provides a reasonable justification for the presence of lncRNA, it also provides a new and global function map of lncRNA [ ], explaining the regulatory function of 3 UTRs [ ]. Recent experiments have provided new evidence for this hypothesis. For example, can compete with gene for binding to the same miRNA hsa-miR-543 in lymphoma [ ]; can compete with gene for binding to the same miRNA hsa-miR-17-5p in hepatocellular carcinoma [ ]. Both non-coding RNAs and coding RNAs can act as ceRNAs according to the ceRNA hypothesis. We focus on the investigation of long non-coding ceRNAs in this work.
机译：长的非编码RNA（lncRNA）参与多种生物学功能[]。但是，关于非编码RNA与其他类型的RNA的功能和调控机制知之甚少[]。一些早期的研究发现，RNA可以通过竞争结合相同的miRNA来影响其他RNA的表达水平。基于这些早期发现，Pandolfi提出了竞争性内源RNA（ceRNA）假设[]。这种ceRNA假设表明，非编码RNA和编码RNA将与mRNA竞争广泛，以与相同的miRNA结合。这种ceRNA假设不仅为lncRNA的存在提供了合理的依据，而且还提供了lncRNA的新的全局功能图[]，解释了3个UTR的调控功能[]。最近的实验为这一假设提供了新的证据。例如，可以与基因竞争与淋巴瘤中相同的miRNA hsa-miR-543结合[]；可以与肝细胞癌中与相同miRNA hsa-miR-17-5p结合的基因竞争[]。根据ceRNA假设，非编码RNA和编码RNA均可充当ceRNA。在这项工作中，我们着重研究长的非编码ceRNA。

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