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PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy

机译：PDCD4缺乏改善2型糖尿病心肌病大鼠模型的左心室重构和胰岛素抵抗

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Diabetic cardiomyopathy (DCM) is characterized by cardiac remodeling, dysfunction, and insulin resistance; however, the underlying mechanism has not been fully elucidated. Programmed cell death 4 (PDCD4) is a novel inflammation and apoptosis gene, but its role in type 2 DCM remains elusive. We aimed to determine if PDCD4 intervention improves DCM by affecting left ventricular remodeling, function, and insulin resistance.

机译：糖尿病性心肌病（DCM）的特征在于心脏重塑，功能障碍和胰岛素抵抗。然而，尚未完全阐明其潜在机制。程序性细胞死亡4（PDCD4）是一种新型的炎症和凋亡基因，但其在2型DCM中的作用仍然难以捉摸。我们旨在确定PDCD4干预是否通过影响左心室重构，功能和胰岛素抵抗来改善DCM。

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期刊名称 BMJ Open Diabetes Research Care
作者
Jie Zhang; Meng Zhang; Zhi Yang; Shanying Huang; Xiao Wu; Lei Cao; Xiaohong Wang; Qian Li; Na Li; Fei Gao;
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作者单位

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年(卷),期 2020(8),1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
cardiac diabetic complication; cell and molecular biology;

机译：心脏糖尿病并发症;细胞和分子生物学;

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专利

1. Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients [J] . Chen Die Yang, Ying Shen, Lin Lu, Cardiovascular Diabetology . 2019,第1期

机译：非糖尿病患者心肌梗死后胰岛素抵抗和血糖异常与左心室重构有关
2. Exercise training ameliorates matrix metalloproteinases 2 and 9 messenger RNA expression and mitigates adverse left ventricular remodeling in streptozotocin-induced diabetic rats [J] . Flávio S. Silva, Raul H. Bortolin, Diego N. Araújo, Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology . 2017,第期

机译：运动训练改善基质金属蛋白酶2和9信使RNA表达和减轻链脲佐菌素诱导的糖尿病大鼠中的不良左心室重塑
3. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy [J] . DongB., YuQ.T., DaiH.Y., Journal of the American College of Cardiology . 2012,第8期

机译：糖尿病心肌病大鼠模型中血管紧张素转换酶2过表达改善左心室重构和功能
4. Prediction of long-term reverse left ventricular remodeling after revascularization or medical treatment in patients with ischemic cardiomyopathy: A comparative study between SPECT and MRI. [C] . Skala Tomas, Hutyra Martin, Vaclavik Jan, International Congress on Coronary Artery Disease . 2011

机译：缺血性心肌病患者血运重建后长期反向左心室重塑的预测：SPECT和MRI的比较研究。
5. Myocardial Energetic Alterations in Post Myocardial Infarction Left Ventricular Remodeling, Hibernating Myocardium and Pacing Induced Congestive Heart Failure and Amelioration with Stem Cell Transplantation [D] . Jameel, Mohammad Nurulqadr. 2011

机译：心肌梗死后左心室重构，冬眠和起搏引起的充血性心力衰竭和干细胞移植改善心肌的能量变化
6. Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients [O] . Chen Die Yang, Ying Shen, Lin Lu, 2019

机译：非糖尿病患者心肌梗死后胰岛素抵抗和血糖异常与左心室重构有关
7. PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy [O] . Jie Zhang, Meng Zhang, Zhi Yang, 2020

机译：PDCD4缺乏改善了2型糖尿病心肌病的大鼠模型中的左心室重塑和胰岛素抗性

PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy

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