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Assessing small airway disease in GLI versus NHANES III based spirometry using area under the expiratory flow-volume curve

机译:使用呼气流量曲线下的面积评估基于GLI和NHANES III的肺活量测定法中的小气道疾病

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摘要

Spirometry interpretation is influenced by the predictive equations defining lower limit of normal (LLN), while ‘distal’ expiratory flows such as forced expiratory flow at 50% FVC (FEF ) are important functional parameters for diagnosing small airway disease (SAD). Area under expiratory flow-volume curve (AEX) or its approximations have been proposed as supplemental spirometric assessment tools. We compare here the performance of AEX in differentiating between normal, obstruction, restriction, mixed defects and SAD, as defined by Global Lung Initiative (GLI) or National Health and Nutrition Examination Survey (NHANES) III reference values, and using various predictive equations for FEF .
机译:肺量测定法的解释受定义正常下限(LLN)的预测方程式的影响,而“远距离”呼气流量,例如50%FVC(FEF)下的强制呼气流量,是诊断小气道疾病(SAD)的重要功能参数。呼气流量曲线下面积(AEX)或其近似值已被建议作为补充肺功能评估工具。根据全球肺部倡议(GLI)或国家健康与营养检查调查(NHANES)III参考值的定义,我们在这里比较了AEX在区分正常,阻塞,限制,混合缺陷和SAD方面的性能,并使用了各种预测方程式外汇基金。

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