首页> 美国卫生研究院文献>BMJ Open >Cost-effectiveness of point-of-care viscoelastic haemostatic assays in the management of bleeding during cardiac surgery: protocol for a prospective multicentre pragmatic study with stepped-wedge cluster randomised controlled design and 1-year follow-up (the IMOTEC study)
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Cost-effectiveness of point-of-care viscoelastic haemostatic assays in the management of bleeding during cardiac surgery: protocol for a prospective multicentre pragmatic study with stepped-wedge cluster randomised controlled design and 1-year follow-up (the IMOTEC study)

机译:现场粘弹性止血分析在心脏手术中出血管理中的成本效益:前瞻性多中心语用研究的协议采用阶梯楔形群随机对照设计和1年随访(IMOTEC研究)

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摘要

During cardiac surgery-associated bleeding, the early detection of coagulopathy is crucial. However, owing to time constraints or lack of suitable laboratory tests, transfusion of haemostatic products is often inappropriately triggered, either too late (exposing to prolonged bleeding and thus to avoidable administration of blood products) or blindly to the coagulation status (exposing to unnecessary haemostatic products administration in patients with no coagulopathy). Undue exposition to transfusion risks and additional healthcare costs may arise. With the perspective of secondary care-related costs, the IMOTEC study (Intérêt MédicO-économique de la Thrombo-Elastographie, dans le management transfusionnel des hémorragies péri-opératoires de chirurgies Cardiaques sous circulation extracorporelle) aims at assessing the cost-effectiveness of a point-of-care viscoelastic haemostatic assay (VHA: RoTem or TEG)-guided management of bleeding. Among several outcome measures, particular emphasis will be put on quality of life with a 1-year follow-up.
机译:在心脏手术相关的出血期间,早期发现凝血病至关重要。但是,由于时间限制或缺乏合适的实验室测试,止血产品的输血常常被不恰当地触发,或者为时已晚(可能导致出血时间延长,从而避免血液制品的使用)或对凝结状态视而不见(可能导致不必要的止血)没有凝血病的患者服用产品)。过度暴露于输血风险可能会导致额外的医疗费用。从与二级保健相关的成本的角度来看,IMOTEC的研究(国际血栓弹性成像医学研究,血液外科血液循环管理管理课程)旨在评估某一点的成本效益。护理的粘弹性止血测定(VHA:RoTem或TEG)指导的出血处理。在一些结果指标中,将特别重视生活质量,并进行为期一年的随访。

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