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首页> 美国卫生研究院文献>AAPS PharmSciTech >Dry granulation and compression of spray-dried plant extracts
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Dry granulation and compression of spray-dried plant extracts

机译：喷雾干燥的植物提取物的干法制粒和压片

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The purpose of this research was to evaluate the influence of dry granulation parameters on granule and tablet properties of spray-dried extract (SDE) fromMaytenus ilicifolia, which is widely used in Brazil in the treatment of gastric disorders. The compressional behavior of the SDE and granules of the SDE was characterized by Heckel plots. The tablet properties of powders, granules, and formulations containing a high extract dose were compared. The SDE was blended with 2% magnesium stearate and 1% colloidal silicon dioxide and compacted to produce granules after slugging or roll compaction. The influences of the granulation process and the roll compaction force on the technological properties of the granules were studied. The flowability and density of spray-dried particles were improved after granulation. Tablets produced by direct compression of granules showed lower crushing strength than the ones obtained from nongranulated material. The compressional analysis by Heckel plots revealed that the SDE undergoes plastic deformation with a very low tendency to rearrangement at an early stage of compression. On the other hand, the granules showed an intensive rearrangement as a consequence of fragmentation and rebounding. However, when the compaction pressure was increased, the granules showed plastic deformation. The mean yield pressure values showed that both granulation techniques and the roll compaction force were able to reduce the material's ability to undergo plastic deformation. Finally, the tablet containing a high dose of granules showed a close dependence between crushing strength and the densification degree of the granules (ie, roll compaction force).
机译：这项研究的目的是评估干制粒参数对Maytenus ilicifolia喷雾干燥提取物（SDE）的颗粒和片剂性质的影响，Maytenus ilicifolia在巴西广泛用于治疗胃病。用Heckel图表征SDE和SDE颗粒的压缩行为。比较了含有高提取剂量的粉末，颗粒和制剂的片剂性质。将SDE与2％的硬脂酸镁和1％的胶体二氧化硅混合，并在压片或辊压后压实以产生颗粒。研究了造粒工艺和辊压实力对颗粒工艺性能的影响。造粒后，喷雾干燥颗粒的流动性和密度得到改善。通过直接压制颗粒制成的片剂显示出比从非粒状材料获得的片剂更低的抗碎强度。通过Heckel曲线进行的压缩分析显示，SDE发生塑性变形，在压缩的早期阶段发生重新排列的可能性非常低。另一方面，由于碎裂和反弹，颗粒显示出强烈的重排。然而，当增加压实压力时，颗粒显示出塑性变形。平均屈服压力值表明造粒技术和辊压实力均能够降低材料的塑性变形能力。最后，含有高剂量颗粒的片剂显示出压碎强度与颗粒的致密化程度（即，压实力）之间密切​​相关。

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