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首页> 美国卫生研究院文献>Brain Sciences >Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study
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Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study

机译：实验性颅脑外伤和呕吐功能障碍大鼠的膀胱测量：一项时程研究

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Traumatic brain injuries (TBIs) are a serious public health issue worldwide with increased mortality as well as severe disabilities and injuries caused by falls and road accidents. Unfortunately, there is no approved therapy for TBIs, and bladder dysfunction is a striking symptom. Accordingly, we attempted to analyze bladder dysfunction and voiding efficiency in rats with a TBI at different time-course intervals. Time-dependent analyses were scheduled from the next day until four weeks after a TBI. Experimental animals were grouped and analyzed under the above conditions. Cystometric measurements were used for this analysis and were further elaborated as external urethral sphincter electromyographic (EUS-EMG) activity and cystometrogram (CMG) measurements. Moreover, magnetic resonance imaging (MRI) studies were conducted to investigate secondary injury progression in TBI rats, and results were compared to normal control (NC) rats. Results of EUS-EMG revealed that the burst period, active period, and silent period in TBI rats were drastically reduced compared to NC rats, but they increased later and reached a stagnant phase. Likewise, in CMG measurements, bladder function, the voided volume, and voiding efficiency decreased immediately after the TBI, and other parameters like the volume threshold, inter-contraction interval, and residual volume drastically increased. Later, those levels changed, and all observed results were compared to NC rats. MRI results revealed the prevalence of cerebral edema and the progression of secondary injury. All of the above-stated results of the experiments were extensively substantiated. Thus, these innovative findings of our study model will surely pave the way for new therapeutic interventions for TBI treatment and prominently highlight their applications in the field of neuroscience in the future.
机译：颅脑外伤（TBI）是世界范围内的严重公共卫生问题，其死亡率增加以及因摔倒和交通事故引起的严重残疾和伤害。不幸的是，目前尚无针对TBI的批准疗法，并且膀胱功能障碍是一个明显的症状。因此，我们试图分析在不同时间间隔的TBI大鼠的膀胱功能障碍和排尿效率。时间依赖性分析的时间安排为从第二天到TBI后的四个星期。在上述条件下对实验动物进行分组和分析。膀胱测量仪用于该分析，并进一步阐述为外部尿道括约肌肌电图（EUS-EMG）活性和膀胱造影图（CMG）测量。此外，进行了磁共振成像（MRI）研究以研究TBI大鼠的继发性损伤进展，并将结果与​​正常对照组（NC）进行了比较。 EUS-EMG的结果显示，与NC大鼠相比，TBI大鼠的爆发期，活跃期和静默期大大减少，但后来增加，达到停滞期。同样，在CMG测量中，在TBI之后，膀胱功能，排尿体积和排尿效率立即降低，其他参数（例如体积阈值，收缩间隔和残余体积）急剧增加。后来，这些水平发生了变化，并将所有观察到的结果与NC大鼠进行了比较。 MRI结果显示脑水肿的流行和继发性损伤的进展。上述所有上述实验结果均得到充分证实。因此，我们研究模型的这些创新发现必将为TBI治疗的新治疗手段铺平道路，并在未来着重强调其在神经科学领域的应用。

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