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首页> 美国卫生研究院文献>Brazilian Journal of Psychiatry >Virginia Woolf neuroprogression and bipolar disorder
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Virginia Woolf neuroprogression and bipolar disorder

机译：弗吉尼亚·伍尔夫（Virginia Woolf）神经进步和躁郁症

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Family history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also known that patients with early childhood trauma present earlier onset of bipolar disorder, increased number of manic episodes, and more suicide attempts. We have recently reported that childhood trauma partly mediates the effect of family history on bipolar disorder diagnosis. In light of these findings from the scientific literature, we reviewed the work of British writer Virginia Woolf, who allegedly suffered from bipolar disorder. Her disorder was strongly related to her family background. Moreover, Virginia Woolf was sexually molested by her half siblings for nine years. Her bipolar disorder symptoms presented a pernicious course, associated with hospitalizations, suicidal behavioral, and functional impairment. The concept of neuroprogression has been used to explain the clinical deterioration that takes places in a subgroup of bipolar disorder patients. The examination of Virgina Woolf’s biography and art can provide clinicians with important insights about the course of bipolar disorder.
机译：家族史和创伤经历是与躁郁症相关的因素。已知双极先证者的亲属中双相情感障碍的终生风险对于一级亲属为5-10％，对于单卵双胞胎为40-70％。还众所周知，患有儿童早期创伤的患者出现双相情感障碍的发作较早，躁狂发作的次数增加，自杀企图增加。我们最近报道，儿童期创伤在一定程度上介导了家族史对双相情感障碍诊断的影响。根据科学文献中的这些发现，我们回顾了据称患有双相情感障碍的英国作家弗吉尼亚·伍尔夫的作品。她的疾病与她的家庭背景密切相关。而且，弗吉尼亚·伍尔夫（Virginia Woolf）被同父异母的兄弟姐妹性骚扰了九年。她的躁郁症症状表现出一种恶性病程，与住院，自杀行为和功能障碍有关。神经进程的概念已被用来解释双相情感障碍患者亚组中发生的临床恶化。对维珍娜·伍尔夫（Virginia Woolf）的传记和艺术的考察可以为临床医生提供有关躁郁症病程的重要见解。

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