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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Comparative Analysis of Titers of Antibody against Measles Virus in Sera of Vaccinated and Naturally Infected Japanese Individuals of Different Age Groups
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Comparative Analysis of Titers of Antibody against Measles Virus in Sera of Vaccinated and Naturally Infected Japanese Individuals of Different Age Groups

机译：接种疫苗和自然感染日本不同年龄人群血清中麻疹病毒抗体滴度的比较分析

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The anti-measles virus (MV) antibody titers in the sera of vaccinees and naturally infected individuals of different age groups were measured to help assess the efficacy of the current MV vaccination in Japan. Neutralizing (NT) antibody titers induced by vaccination were 23.2 times lower than those induced by natural infection and declined significantly by age 20. The once-decreased NT antibody titers of the vaccinees increased 23.6 times during their twenties to titers comparable to those of naturally infected individuals of the same age, implying the possible occurrence of natural infection in vaccinees with decreased anti-MV immunity. Although the current field strains in Japan, types D3 and D5, were reported to differ antigenically from each other and from vaccine strains (type A) to some extent, as demonstrated by different reactivities to monoclonal antibodies, the sera of vaccinees neutralized the two types of field strains and the vaccine strain with the same efficiency. This result suggests that the current vaccine strain would be suitable to elicit protection against types D3 and D5, as long as viral antigenicity is concerned. However, when compared at given hemagglutination inhibition titers, NT antibody titers of vaccinees were 21.1 to 23.2 times lower than those of naturally infected individuals, suggesting a qualitative difference(s) of anti-MV antibodies between the two groups. It should be emphasized that protective immunity induced by the one-dose vaccination currently implemented in Japan may not be strong enough to ensure lifelong immunity. A two-dose vaccination program with higher vaccination coverage needs to be considered in order to effectively control measles in Japan.
机译：测量了疫苗接种者和不同年龄组的自然感染者血清中的抗麻疹病毒（MV）抗体滴度，以帮助评估日本目前的MV疫苗接种的功效。疫苗诱导的中和（NT）抗体滴度比自然感染诱导的中和（NT）抗体滴度低2 3.2 倍，并且到20岁时显着下降。疫苗的NT抗体滴度曾经下降的比例提高了2 3.6 在20年代达到与相同年龄的自然感染个体相当的滴度，这意味着抗MV免疫力降低的疫苗可能会发生自然感染。据报道，日本目前的田间毒株D3和D5在抗原学上和疫苗株（A型）在抗原学上有所不同，如对单克隆抗体的反应性不同，但疫苗的血清中和了这两种场菌株和疫苗菌株具有相同的效率。该结果表明，只要涉及病毒抗原性，当前的疫苗株将适合引发针对D3和D5型的保护。但是，与给定的血凝抑制效价相比，被疫苗接种者的NT抗体效价比自然感染个体的NT抗体效价低2 1.1 至2 3.2 倍，表明在质量上有差异）两组之间的抗MV抗体。应该强调的是，日本目前实施的一剂疫苗接种诱导的保护性免疫力可能不足以确保终生免疫力。为了有效控制日本的麻疹，需要考虑接种疫苗剂量更高的两剂疫苗接种方案。

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