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The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division

机译：从磷酸酶角度看G2-M过渡：减数分裂分裂的新视野

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The three transitions of the mitotic cycle involving Cdk1-Cyclin B. During the G2-phase, Cyclin B accumulates and binds to Cdk1 that is phosphorylated at T161 by CAK and at Y15 and T14 by Wee1/Myt1. The complex is thus inactive. At the G2-to-M transition, Wee1/Myt1 are turned off while Cdc25 is turned on, promoting Y15 and T14 dephosphorylations and Cdk1 activation. During M-phase, Cdk1-Cyclin B phosphorylates many mitotic substrates, including Wee1/Myt1 and Cdc25. At the end of M-phase, MPF activates the Cyclin proteolytic degradation system, thus inducing its own inactivation

机译：涉及Cdk1-细胞周期蛋白B的有丝分裂周期的三个过渡。在G2期，细胞周期蛋白B积累并结合到Cdk1，后者在T161被CAK磷酸化，在Y15和T14被Wee1 / Myt1磷酸化。因此，该复合体处于非活动状态。在从G2到M的过渡过程中，当Cdc25打开时Wee1 / Myt1被关闭，从而促进Y15和T14的去磷酸化以及Cdk1的激活。在M期，Cdk1-细胞周期蛋白B磷酸化许多有丝分裂的底物，包括Wee1 / Myt1和Cdc25。在M期结束时，MPF激活Cyclin蛋白水解降解系统，从而导致自身失活。

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期刊名称 Cell Division
作者
Tom Lemonnier; Aude Dupré; Catherine Jessus;
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作者单位

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年(卷),期 2020(15),-1
年度 2020
页码 -1
总页数 17
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
Cell division; Meiotic division; Oocyte; Protein phosphatases; Protein kinases; Protein phosphorylation; PP2A; Cdk1; PKA;

机译：细胞分裂;减数分裂;卵母细胞;蛋白质磷酸酶;蛋白质激酶;蛋白质磷酸化;PP2A;Cdk1;PKA;

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专利

1. The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division [J] . Tom Lemonnier, Aude Dupré, Catherine Jessus Cell Division . 2020,第1期

机译：从磷酸酶的角度来看G2-〜M转变：减数分裂划分的新视野
2. Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. [J] . N K Tonks, M F Cicirelli, C D Diltz, Molecular and Cellular Biology . 1990,第2期

机译：微量注射低Mr人胎盘蛋白酪氨酸磷酸酶对非洲爪蟾卵母细胞减数分裂分裂诱导的影响。
3. The CYCLIN-A CYCA1;2/TAM Is Required for the Meiosis I to Meiosis II Transition and Cooperates with OSD1 for the Prophase to First Meiotic Division Transition [J] . Isabelle dErfurth, Laurence Cromer, Sylvie Jolivet, PLoS Genetics . 2010,第6期

机译：CYCLIN-A CYCA1; 2 / TAM是减数分裂I到减数分裂II过渡所必需的，并且与OSD1配合用于第一次减数分裂的过渡
4. Transitioning from the traditional divisional dataset to the Global Historical Climatology Network-Daily gridded divisional dataset [C] . Chris Fenimore, Derek Arndt, Karin Gleason, AMS annual meeting . 2011

机译：从传统的分区数据集过渡到全球历史气候学网络-每日网格化分区数据集
5. Oocyte Meiotic Cell Division: Spindle Assembly, Chromosome Segregation, and Cytokinesis [D] . ?Schlientz, Aleesa Joelle 2020

机译：卵母细胞减数分裂：主轴组件，染色体隔离和细胞因子
6. The CYCLIN-A CYCA1;2/TAM Is Required for the Meiosis I to Meiosis II Transition and Cooperates with OSD1 for the Prophase to First Meiotic Division Transition [O] . Isabelle dErfurth, Laurence Cromer, Sylvie Jolivet, 2010

机译：CYCLIN-A CYCA1; 2 / TAM是减数分裂I到减数分裂II过渡所必需的并与OSD1配合用于第一次减数分裂过渡的前期
7. The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division [O] . Tom Lemonnier, Aude Dupré, Catherine Jessus 2020

机译：从磷酸酶的角度来看G2-〜M转变：减数分裂划分的新视野
8. Proof That Univalent Chromosomes Undergoing Equational Division at Anaphase I Are Not Lost During the Second Meiotic Division [R] . Weber, D. F. 1980

机译：在后期进行等分术的单价染色体的证据我在第二次减数分裂期间不会丢失

The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division

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