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首页> 美国卫生研究院文献>Clinical Pediatric Endocrinology >Efficacy of zinc supplementation on growth and IGF-1 in prepubertal childrenwith idiopathic short statures and low serum zinc levels
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Efficacy of zinc supplementation on growth and IGF-1 in prepubertal childrenwith idiopathic short statures and low serum zinc levels

机译：锌补充对青春期前儿童生长和IGF-1的影响特发性矮小和血清锌水平低

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We investigated the effect of zinc supplementation on growth and serum IGF-1 levels in 10prepubertal Japanese children with idiopathic short statures, who had serum zinc levels ofless than 80 µg/dL. Subjects were started on oral zinc supplementation at a dose of 25 mgonce daily. In three children, the doses were increased by 50 mg once daily during thestudy period of 12 mo. The serum zinc levels rose in all subjects and reached a normalrange (beyond 80 µg/dL). However, it was found that zinc supplementation did not promotegrowth. Although the mean IGF-1 standard deviations significantly increased, the majoritydid not reach the normal range. There were no significant adverse events other than mildgastrointestinal symptoms in 4 out of 10 subjects during the supplementation period. Themost likely reason why growth was not promoted is that the zinc supplementation dosage wasnot enough to stimulate IGF-1 generation and subsequent growth velocity.
机译：我们调查了补锌对10种生长和血清IGF-1水平的影响患有特发性矮小身材的日本青春期前儿童的血清锌水平为小于80 µg / dL。开始以25 mg的剂量口服锌补充剂每天一次。在三名儿童中，在服药期间每天一次增加剂量50毫克。学习期为12个月。所有受试者的血清锌水平均上升并达到正常范围（超过80 µg / dL）。但是，发现补锌并不能促进增长。尽管平均IGF-1标准差显着增加，但大多数没有达到正常范围。除轻度无其他重大不良事件在补充期间，十分之四的受试者出现了胃肠道症状。的不能促进生长的最可能原因是补锌剂量为不足以刺激IGF-1的产生和随后的生长速度。

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