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首页> 美国卫生研究院文献>Dose-Response >The Selby-Russell Dispute Regarding the Nonreporting of Critical Data in the Mega-Mouse Experiments of Drs William and Liane Russell That Spanned Many Decades: What Happened Current Status and Some Ramifications
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The Selby-Russell Dispute Regarding the Nonreporting of Critical Data in the Mega-Mouse Experiments of Drs William and Liane Russell That Spanned Many Decades: What Happened Current Status and Some Ramifications

机译：关于William和Liane Russell博士跨越数十年的大型小鼠实验中未报告关键数据的Selby-Russell争议：发生了什么当前状况和一些后果

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The Russells began their studies of the hereditary effects of radiation in the late 1940s, and their experiments contributed much to what is known about the induction of gene mutations in mice. I had a close association with them for about 26 years, and they relied on me considerably for database management and statistical support. In 1994, I was shocked to discover that, in experiments on males, they had failed to report numerous spontaneous mutations that arose during the perigametic interval and were detected as clusters of mutations. I realized that their nondisclosure of this information meant that the decades-long application of their data to estimate hereditary risks of radiation to humans using the doubling-dose approach had resulted in a several-fold overestimation of risk. I accordingly reported the situation to funding agencies. The resulting complicated situation is referred to here as the Selby-Russell Dispute. Highlights of the resulting investigation, as well as what occurred afterward, are described, and reasons will be provided to show why, in my opinion, the hereditary risk from radiation in humans was likely overestimated by at least 10-fold because the Russells decided not to report critical information from their massive experiments.
机译：罗素（Russells）在1940年代后期开始研究放射线的遗传效应，他们的实验大大有助于诱导小鼠基因突变。我与他们有大约26年的紧密联系，他们在数据库管理和统计支持方面相当依赖我。 1994年，我很震惊地发现，在对雄性动物进行的实验中，他们未能报告在自体放热期间出现的许多自发突变，并被检测为突变簇。我意识到，他们没有公开这些信息，意味着使用他们的数据数十年来使用倍剂量方法估计对人类辐射的遗传风险，导致对风险的高估了几倍。因此，我向筹资机构报告了这种情况。由此产生的复杂情况在此称为塞尔比-罗素争端。描述了所得调查的重点以及随后发生的事，并提供了理由说明我认为为什么人类辐射引起的遗传风险可能被高估了至少10倍，因为罗素决定不报告他们大规模实验的关键信息。

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