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Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer

机译：Rab8 GTPase通过直接调节人非小细胞肺癌中的表面表达来调节Klotho介导的细胞生长和进程抑制

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摘要

The (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho without identifying precise molecular mechanisms or interactions.

机译：（KL）基因是一种抗衰老基因，最近已经显示出它还可以充当一般的肿瘤抑制因子。但是，目前只有很少的关于潜在分子信号调节Klotho的信息，而没有确定精确的分子机制或相互作用。

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期刊名称 EBioMedicine
作者
Bo Chen; Shuhong Huang; Thomas R. Pisanic; II; Alejandro Stark; Yong Tao; Bei Cheng; Yue Li; Yunyan Wei; Weihong Zhao; Tza-Huei Wang; Jianqing Wu;
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年(卷),期 2019(49),-1
年度 2019
页码 -1
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
Rab8; Klotho; Surface expression; Non-small cell lung cancer; Wnt signaling; Cell phenotype;

机译：Rab8;Klotho;表面表达;非小细胞肺癌;Wnt信号转导;细胞表型;

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专利

1. Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer [J] . Bo Chen, Shuhong Huang, II Thomas R. Pisanic, EBioMedicine . 2019,第4期

机译：Rab8 GTPase通过直接调节人非小细胞肺癌中的表面表达来调节Klotho介导的细胞生长和进程抑制
2. miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression [J] . SalimH., ArvanitisA., dePetrisL., Genes, Chromosomes and Cancer . 2013,第10期

机译：miRNA-214与人类非小细胞肺癌的侵袭性有关，并直接调节α蛋白激酶2的表达
3. Increased insulin-like growth factor 1 receptor (IGF1R) expression in small cell lung cancer and the effect of inhibition of IGF1R expression by RNAi on growth of human small cell lung cancer NCI-H446 cell [J] . Wang Zhigang, Lu Pingfang, Liang Zhu, Growth Factors . 2015,第1a6期

机译：小细胞肺癌中胰岛素样生长因子1受体（IGF1R）表达的增加以及RNAi抑制IGF1R表达对人小细胞肺癌NCI-H446细胞生长的影响
4. The Proliferative Inhibition and Apoptotic Mechanism of Saikosaponin D in Human Non-Small Cell Lung Cancer A549 Cells [C] . Jiang Dong, Yang Ru-song, Zheng Shi-ying, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：皂苷D在人非小细胞肺癌A549细胞中的增殖抑制及其凋亡机制
5. Abberant activation and inhibition of the epidermal growth factor receptor in non-small cell lung cancer. [D] . Peet, Chimera R. 2009

机译：非小细胞肺癌的异常激活和表皮生长因子受体的抑制。
6. Silibinin Inhibits Human Non-small Cell Lung Cancer Cell Growth through Cell Cycle Arrest by Modulating Expression and Function of Key Cell Cycle Regulators [O] . Samiha Mateen, Alpna Tyagi, Chapla Agarwal, -1

机译：通过调节关键细胞周期调节剂的表达和功能通过细胞循环捕获抑制人非小细胞肺癌细胞生长
7. Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer [O] . Bo Chen, Shuhong Huang, Thomas R. Pisanic II, 2019

机译：Rab8 GTPase通过直接调节其非小细胞肺癌的表面表达，调节Klotho介导的细胞生长和进展的抑制作用

Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer

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