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首页> 美国卫生研究院文献>Endocrine Connections >MEN1-associated primary hyperparathyroidism in the Spanish Registry: clinical characterictics and surgical outcomes
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MEN1-associated primary hyperparathyroidism in the Spanish Registry: clinical characterictics and surgical outcomes

机译：MEN1相关的西班牙原发性甲状旁腺功能亢进症：临床特征和手术结局

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Primary hyperparathyroidism is the most frequent manifestation of multiple endocrine neoplasia type 1 (MEN1) syndrome. Bone and renal complications are common. Surgery is the treatment of choice, but the best timing for surgery is controversial and predictors of persistence and recurrence are not well known. Our study describes the clinical characteristics and the surgical outcomes, after surgery and in the long term, of the patients with MEN1 and primary hyperparathyroidism included in the Spanish Registry of Multiple Endocrine Neoplasia, Pheochromocytomas and Paragangliomas (REGMEN). Eighty-nine patients (49 men and 40 women, 34.2 ± 13 years old) were included. Sixty-four out of the 89 underwent surgery: a total parathyroidectomy was done in 13 patients, a subtotal parathyroidectomy in 34 and a less than subtotal parathyroidectomy in 15. Remission rates were higher after a total or a subtotal parathyroidectomy than after a less than subtotal (3/4 and 20/22 vs 7/12,
机译：原发性甲状旁腺功能亢进是多发性内分泌肿瘤1型（MEN1）综合征的最常见表现。骨和肾并发症很常见。手术是一种选择的治疗方法，但是手术的最佳时机仍存在争议，并且持续性和复发的预测指标尚不为人所知。我们的研究描述了西班牙多发性内分泌肿瘤，嗜铬细胞瘤和神经节瘤（REGMEN）注册表中包括的MEN1和原发性甲状旁腺功能亢进症患者的临床特征和手术后及长期的手术结局。包括89例患者（49例男性和40例女性，34.2±13岁）。 89例中有64例进行了手术：13例进行了全副甲状腺切除术，34例进行了次全甲状腺切除术，15例小于全次甲状腺切除术，缓解率高于全切除或次全切除术后。 （3/4和20/22对7/12，

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