In 1917, Giovanni Di Guglielmo, at that time a young collaborator of Adolfo Ferrata at the University of Naples, Italy, described in a patient with an hematological disorder characterized by an increased number of granulocytes, erythrocytes and platelets and the presence of precursors of all these elements in circulation. He classified this patient as affected by (erythro-leuko-thrombocythemia), a form that we would nowadays include in the context of myeloproliferative diseases. Until the description of this patient only leukemias characterized by proliferation of myeloid or lymphoid series were known, but the observation of this patient gave Di Guglielmo the idea that primitive bone marrow elements can abnormally proliferate not only along the myeloid line, but also along the erythropoietic and thrombopoietic lines. In particular, he hyphothesized that generalized erythroblastic proliferation throughout all organs of the body could be expected. Ten years later, he described in Haematologica two cases of what he had claimed would ultimately be found: .
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机译：1917年，当时那不勒斯大学的Adolfo Ferrata的一位年轻合作者Giovanni Di Guglielmo描述了一名血液学疾病患者，其特征是粒细胞，红细胞和血小板数量增加，并且存在所有前体这些元素在流通。他将该患者归类为患有（红细胞-白血栓性红细胞增多症），这是我们如今在骨髓增生性疾病中所包括的一种形式。直到对该患者的描述之前，仅知道以髓样或淋巴样系列增生为特征的白血病，但对该患者的观察使Di Guglielmo认为原始的骨髓成分不仅可以沿髓样线而且沿红细胞生成异常增殖。和血小板生成系。他特别假设，可以预期到全身所有器官都将出现普遍的红细胞增生。十年后，他在血液学杂志中描述了他声称最终会被发现的两个案例：。
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