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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Disease Severity Associated with Presence in Subgingival Plaque of Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans and Tannerella forsythia Singly or in Combination as Detected by Nested Multiplex PCR
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Disease Severity Associated with Presence in Subgingival Plaque of Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans and Tannerella forsythia Singly or in Combination as Detected by Nested Multiplex PCR

机译：巢式多重PCR检测的疾病严重性与牙龈卟啉单胞菌放线杆菌聚合菌和连翘单胞菌的龈下菌斑的存在有关

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This study used a nested multiplex PCR method to detect three periodontal pathogens in subgingival plaque collected before treatment and at 2 and 6 months posttreatment from 107 patients with severe, generalized periodontitis. The proportions of the patients who harbored these bacteria before periodontal treatment were as follows: Tannerella forsythia, 81%; Porphyromonas gingivalis, 78%; and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, 47%. At 2 months posttreatment there was a significant reduction in the numbers of patients harboring P. gingivalis (46%; P < 0.001) or T. forsythia (63%; P = 0.043) but not A. actinomycetemcomitans (50%) compared to pretreatment data. At 6 months posttreatment, significantly fewer patients harbored P. gingivalis (43%; P < 0.001); A. actinomycetemcomitans, (31%; P = 0.025), or T. forsythia (63%; P = 0.030). Interestingly, at baseline and at 2 months posttherapy, subjects who harbored only a single pathogen had a greater level of periodontal disease than subjects who harbored two, or all three, of these periodontal pathogens. These data suggest that a reduction in the number of species present may be associated with an increase in the severity of periodontal diseases.
机译：这项研究使用巢式多重PCR方法检测107例重症，广义牙周炎患者在治疗前以及治疗后2和6个月时收集的三种龈下菌斑中的牙周病原体。牙周治疗之前携带这些细菌的患者的比例如下：排毒连翘（Tannerella forsythia），占81％。牙龈卟啉单胞菌，78％;和聚合杆菌（以前的放线杆菌）放线菌，47％​​。与治疗前相比，治疗后2个月，携带牙龈卟啉单胞菌（46％; P <0.001）或连翘（T. Forsythia）（63％; P = 0.043）的患者数量显着减少，而放线菌不包括放线菌（50％）。数据。治疗后6个月，携带牙龈卟啉单胞菌的患者明显减少（43％； P <0.001）； A.放线菌（31％; P = 0.025）或连翘（63％; P = 0.030）。有趣的是，在基线期和治疗后2个月，仅携带一种病原体的受试者的牙周疾病水平要高于携带两种或全部三种这些牙周病原体的受试者。这些数据表明存在的物种数量减少可能与牙周疾病的严重程度增加有关。

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