• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity
【2h】

Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity

机译：特别长寿的人（ELLI）证明了由DNA甲基化时钟计算出的较慢的衰老速率是健康长寿的可能调节剂

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Exceptionally long-lived individuals (ELLI) who are the focus of many healthy longevity studies around the globe are now being studied in Israel. The Israeli Multi-Ethnic Centenarian Study (IMECS) cohort is utilized here for assessment of various DNA methylation clocks. Thorough phenotypic characterization and whole blood samples were obtained from ELLI, offspring of ELLI, and controls aged 53–87 with no familial exceptional longevity. DNA methylation was assessed using Illumina MethylationEPIC Beadchip and applied to DNAm age online tool for age and telomere length predictions. Relative telomere length was assessed using qPCR T/S (Telomere/Single copy gene) ratios. ELLI demonstrated juvenile performance in DNAm age clocks and overall methylation measurement, with preserved cognition and relative telomere length. Our findings suggest a favorable DNA methylation profile in ELLI enabling a slower rate of aging in those individuals in comparison to controls. It is possible that DNA methylation is a key modulator of the rate of aging and thus the ELLI DNAm profile promotes healthy longevity.
机译：以色列目前正在研究全球许多健康长寿研究的重点是长寿个体（ELLI）。这里使用了以色列多民族百岁研究（IMECS）队列来评估各种DNA甲基化时钟。完整的表型特征和全血样品来自ELLI，ELLI的后代以及53-87岁且无家族异常长寿的对照。使用Illumina MethylationEPIC Beadchip评估DNA甲基化，并将其应用于DNAm年龄在线工具以预测年龄和端粒长度。使用qPCR T / S（端粒/单拷贝基因）比率评估端粒的相对长度。 ELLI在DNAm年龄时钟和总体甲基化测量中展示了少年表现，并且保留了认知和相对端粒长度。我们的发现表明，与对照组相比，ELLI中的DNA甲基化状况良好，从而使这些人的衰老速度减慢。 DNA甲基化可能是衰老速率的关键调节剂，因此ELLI DNAm谱可促进健康长寿。

著录项

相似文献

  • 外文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号