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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology
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Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

机译：母马持久繁殖诱导的子宫内膜炎-一个多方面的挑战：从临床方面到免疫发病机制和病理生物学

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摘要

Post-breeding endometritis (i.e., inflammation/infection of the endometrium), is a physiological reaction taking place in the endometrium of mares within 48 h post-breeding, aimed to clear seminal plasma, excess sperm, microorganisms, and debris from the uterine lumen in preparation for the arrival of an embryo. Mares are classified as susceptible or resistant to persistent breeding-induced endometritis (PBIE) based on their ability to clear this inflammation/infection by 48 h post-breeding. Mares susceptible to PBIE, or those with difficulty clearing infection/inflammation, have a deficient immune response and compromised physical mechanisms of defense against infection. Molecular pathways of the innate immune response known to be involved in PBIE are discussed herein. The role of the adaptive uterine immune response on PBIE remains to be elucidated in horses. Advances in the pathobiology of microbes involved in PBIE are also revised here. Traditional and non-traditional therapeutic modalities for endometritis are contrasted and described in the context of clinical and molecular aspects. In recent years, the lack of efficacy of traditional therapeutic modalities, alongside the ever-increasing incidence of antibiotic-resistant microorganisms, has enforced the development of non-traditional therapies. Novel biological products capable of modulating the endometrial inflammatory response are also discussed here as part of the non-traditional therapies for endometritis.
机译：繁殖后子宫内膜炎（即子宫内膜的炎症/感染）是在繁殖后48小时内在母马的子宫内膜中发生的生理反应，旨在清除子宫腔内的精浆，精子，微生物和碎片。为胚胎的到来做准备。根据母马在繁殖后48小时清除炎症/感染的能力，母马被归类为对持久性繁殖诱发的子宫内膜炎（PBIE）敏感或耐药。易患PBIE的母马，或难以清除感染/炎症的母马，免疫反应不足，抵御感染的物理机制受损。本文讨论了已知与PBIE有关的先天免疫应答的分子途径。 PBIE的适应性子宫免疫反应的作用在马中尚待阐明。 PBIE中涉及的微生物的病理学研究进展也在这里进行了修订。子宫内膜炎的传统和非传统治疗方式已在临床和分子方面进行了对比和描述。近年来，传统治疗方法缺乏疗效，加上抗生素耐药性微生物的发病率不断增加，迫使非传统疗法的发展。作为子宫内膜炎的非传统疗法的一部分，本文还将讨论能够调节子宫内膜炎性反应的新型生物产品。

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