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首页> 美国卫生研究院文献>International Journal of Immunopathology and Pharmacology >The use of a new chemical device based on silver and cationicsurfactants as a new approach for daily oral hygiene: A preliminary study on agroup of periodontal patients
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The use of a new chemical device based on silver and cationicsurfactants as a new approach for daily oral hygiene: A preliminary study on agroup of periodontal patients

机译：使用基于银和阳离子的新型化学装置表面活性剂作为日常口腔卫生的一种新方法：对牙周病患者组

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The aim of this study was to evaluate the abatement power of oral microbialloading of a new gel formulation based on the complex silver-2-mercaptobenzoate,chlorhexidine digluconate and didecyldimethylammonium chloride (named ADC)through polymerase chain reaction (PCR). The study sample consists of a group of20 patients with chronic periodontal disease. Patients were over 25 years of ageand did not undergo surgical or non-surgical periodontal treatment in theprevious 6 months. The study sample was allotted into two groups of 10 patientseach, homogeneous by age and sex. The test group received a bottle containingADC gel, while the control group received an identical one containing placebo,similar to ADC in consistence, colour, taste and odour. Sub-gingival samples offour sites, one in each quadrant, of greatest probing depth in each patient wereused. Microbiological analyses were performed at baseline and at day 15. Pairedt test was performed to detect statistical significant reduction in totalbacterial loading and oral pathogens in the study groups. The analysis showed astatistically significant reduction in the total bacterial loading evaluatedpre- and post-treatment ( = 0.029) in the study groups. In thecontrol group, the decrease in total bacterial loading was not significant( = 0.279). Clinically, ADC gel does not have any sideeffects and discomfort such as pain, burning, tingling sensation or numbness andproduces no adverse reactions in time. Our study aimed to evaluate the efficacyof a new chemical formulation with antibacterial properties to use for dailyoral hygiene with a preliminary study. Our results showed a statisticallysignificant reduction in total bacterial loading after treatment, but thelimitations of our study do not allow us to demonstrate the clinical efficacy ofthe ADC gel.
机译：这项研究的目的是评估口腔微生物的减排能力加载基于2-巯基苯甲酸银复合物的新凝胶制剂，氯己定二葡萄糖酸酯和二癸基二甲基氯化铵（命名为ADC）通过聚合酶链反应（PCR）。研究样本包括一组慢性牙周病20例。患者年龄超过25岁并且在手术后未接受手术或非手术牙周治疗前六个月。将研究样本分配给10位患者的两组每个，按年龄和性别均质。测试小组收到了一个装有ADC凝胶，而对照组则接受了相同的含安慰剂的凝胶，在稠度，颜色，味道和气味方面类似于ADC。牙龈下样本每个患者的探查深度最大的四个部位（每个象限一个）是用过的。在基线和第15天进行了微生物分析。进行t检验以检测总的统计学显着降低研究组中的细菌载量和口腔病原体。分析显示评估的总细菌载量统计上显着降低研究组的治疗前和治疗后（= 0.029）。在里面对照组总细菌载量减少不明显（= 0.279）。临床上，ADC凝胶没有任何方面效果和不适，例如疼痛，灼痛，刺痛感或麻木感和不产生任何不良反应。我们的研究旨在评估疗效具有抗菌特性的新化学制剂的日常使用初步研究口腔卫生。我们的结果表明治疗后细菌总数的显着减少，但是我们研究的局限性不允许我们证明ADC凝胶。

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