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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study
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Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study

机译：巴西某农业综合企业集中地区农药和乳腺癌的环境暴露：病例对照研究

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: Breast cancer is a serious public health problem and is the second most prevalent cancer type in the world. The purpose of this article is to evaluate the association between pesticide use and breast cancer in a region of intense agribusiness activity in the state of Mato Grosso, Brazil. : A case-control study was conducted on women living in the city of Rondonópolis, in the south of Mato Grosso state. There were 85 cases of women with confirmed breast cancer and 266 controls who were randomly selected from primary health care users. Bivariate and stratified analyses were performed. Multiple logistic regression was then performed, keeping in the final model the factors with a significance level lower than or equal to 0.05 or considered important according to apriori biological criteria. : In the final model, living near cropland with pesticides (OR: 2.37; CI: 95% 1.78–3.16) and women aged over 50 years who experienced early menarche (OR: 2.08; CI: 95% 1.06–4.12) had a higher risk of developing breast cancer compared to control subjects. : This study highlights the importance of exposure to pesticides as an environmental risk factor for the development of breast cancer among women.
机译：：乳腺癌是严重的公共卫生问题，是世界上第二大流行的癌症。本文的目的是评估巴西马托格罗索州农业综合企业活跃地区农药使用与乳腺癌之间的关联。 ：对居住在马托格罗索州南部Rondonópolis市的妇女进行了病例对照研究。从初级卫生保健使用者中随机选择了85例确诊为乳腺癌的妇女和266例对照。进行了双变量和分层分析。然后进行多重逻辑回归，将最终显着性水平低于或等于0.05或根据先验生物学标准认为重要的因素保留在最终模型中。 ：在最终模型中，居住在农田附近并使用农药（OR：2.37； CI：95％1.78–3.16）和年龄超过50岁且初潮初潮的女性（OR：2.08； CI：95％1.06-4.12）更高与对照组相比，患乳腺癌的风险更高。 ：这项研究强调了暴露于农药的重要性，因为农药是女性乳腺癌发展的环境危险因素。

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