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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Surface-Specific Caries Preventive Effect of an Intervention Comprising Fissure Sealant Povidone-Iodine and Fluoride Varnish in a Remote Indigenous Community in Australia
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Surface-Specific Caries Preventive Effect of an Intervention Comprising Fissure Sealant Povidone-Iodine and Fluoride Varnish in a Remote Indigenous Community in Australia

机译：在澳大利亚一个偏远的土著社区中由一种表面裂缝引起的龋齿的预防作用包括裂缝密封剂聚维酮碘和氟化物清漆。

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摘要

This study evaluates the effect of a topical intervention comprising of fissure sealant, povidone-iodine, and fluoride varnish in preventing caries on occlusal, approximal, and smooth surfaces. This three-year clinical trial was conducted in a remote Indigenous community of Australia. All schoolchildren (age range: 4–17) were invited to participate; those with parental consents to receive three-annual epidemiological examinations and interventions constituted the experimental group, while those with consents for only the epidemiological examination formed a comparison group. The intervention group received an annual application of fissure sealant, povidone–iodine and fluoride varnish for two consecutive years along with the restoration of any cavitated lesions, while the comparison group did not receive any intervention except for the usual care that included emergency treatment and restorations. Incipient and advanced caries were recorded in the permanent dentition while data on confounding variables were collected through questionnaires. Caries increment and progression were the outcome variables. A total of 408 children participated in the baseline examination, 208 finished the study. After adjusting for confounders, the prevented fraction (PF) on occlusal surfaces for advanced caries in the experimental group was 76.1% (mean difference- −0.35, 95% CI: −0.67–0.04), while the PF for progression from incipient to advanced caries was 100%(mean difference- −0.30, 95% CI: −0.52–0.09). The mean number of smooth surfaces that progressed from incipient to advanced caries in the comparison group was more than twice that of the experimental group, the mean difference was −0.25 (95% CI: −0.46–−0.03) with a PF of 61%. The intervention was only effective in preventing advanced caries on occlusal surfaces and in halting the progression of caries on occlusal and smooth surfaces but not on approximal caries.
机译：本研究评估了由裂隙密封剂，聚维酮碘和氟化物清漆组成的局部干预对预防咬合面，近似面和光滑面龋的效果。这项为期三年的临床试验在澳大利亚一个偏远的土著社区中进行。邀请所有小学生（年龄范围：4-17岁）参加；经父母同意接受三年一次流行病学检查和干预的人组成实验组，而仅接受流行病学检查的人组成比较组。干预组连续两年每年接受一次裂隙封闭剂，聚维酮-碘和氟化物清漆的应用，同时修复了所有空化病变，而对照组则没有接受任何干预，除了包括紧急治疗和修复的常规护理外。在恒牙列中记录初期和晚期龋病，而通过问卷调查收集有关混杂变量的数据。龋齿的增加和进展是结果变量。共有408名儿童参加了基线检查，其中208名完成了研究。调整混杂因素后，实验组晚期龋齿的咬合面预防分数（PF）为76.1％（平均差异--0.35，95％CI：-0.67-0.04），而从初期到晚期的PF龋齿为100％（平均差异--0.30，95％CI：-0.52-0.09）。在比较组中，从新生龋到晚期龋的平均光滑表面数量是实验组的两倍以上，平均差异为-0.25（95％CI：-0.46--0.03），PF为61％ 。该干预措施仅能有效防止咬合面上的晚期龋齿，并阻止咬合和光滑表面上的龋齿进展，但不能阻止近似的龋齿。

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