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首页> 美国卫生研究院文献>Integrative Cancer Therapies >Protective Effect of Traditional Chinese Medicine Formula RP on LungMicroenvironment in Pre-Metastasis Stage of Breast Cancer
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Protective Effect of Traditional Chinese Medicine Formula RP on LungMicroenvironment in Pre-Metastasis Stage of Breast Cancer

机译：中药复方RP对肺的保护作用乳腺癌转移前期的微环境

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Inflammatory response and inflammation-induced vascularhyper-permeability were established leading to the abnormalities of thepulmonary microenvironment in pre-metastasis stage of breast cancer. Ruyiping isa commonly used compound drug for clinical treatment of breast cancermetastasis, and is mainly used to treatpulmonary inflammatory diseases. Therefore, this study used ruyiping combinedwith (abbreviated as RP) to investigatetheir inhibitory effect on pre-metastatic microenvironment of lung in 4T1tumor-bearing mice. The permeability oflung tissue was detected by Evans blue method. The localization of S100A8/A9 inlung tissue was obtained by double-labeling immunofluorescence staining. Thelevel of fibrinogen in pre-metastatic microenvironment of lung as well as thelevels of pro-inflammatory factors (interleukin [IL]-1β and IL-6) and chemokines(CXCL2 and CXCL5) in bronchoalveolar lavage fluid was detected by ELISA(enzyme-linked immunosorbent assay). From the experimentalresults, RP could protect the integrity of microvascular, inhibit the release ofS100A8/A9, reduce the extravasation of fibrinogen, and decrease the expressionsof IL-1β, IL-6, CXCL2, and CXCL5. RP could inhibit theextravasation of fibrinogen by protecting pulmonary vascular integrity and theninterrupted its interaction with carcinoma in situ, thereby inhibiting theformation of inflammatory pre-metastatic microenvironment.
机译：炎症反应和炎症诱导的血管建立了通透性过高导致的异常乳腺癌转移前阶段的肺微环境如意平是一种用于乳腺癌临床治疗的常用复合药物转移，主要用于治疗肺炎性疾病。因此，本研究采用如意平联合与（缩写为RP）一起进行调查对4T1期肺转移前微环境的抑制作用荷瘤小鼠。磁导率用伊文思蓝法检测肺组织。 S100A8 / A9的本地化通过双标记免疫荧光染色获得肺组织。的肺转移前微环境中纤维蛋白原的水平促炎因子（白介素[IL]-1β和IL-6）和趋化因子的水平ELISA检测支气管肺泡灌洗液中的CXCL2和CXCL5（酶联免疫吸附测定）。从实验结果，RP可以保护微血管的完整性，抑制其释放S100A8 / A9，减少纤维蛋白原的渗出并减少其表达IL-1β，IL-6，CXCL2和CXCL5的表达。 RP可以抑制通过保护肺血管完整性然后使纤维蛋白原外渗中断了它与原位癌的相互作用，从而抑制了炎性转移前微环境的形成。

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