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首页> 美国卫生研究院文献>Iranian Journal of Medical Sciences >Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review
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Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review

机译：脊髓损伤诱导神经源性膀胱大鼠干细胞移植后的尿动力学参数：叙事回顾。

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Neurogenic bladder (NGB) secondary to spinal cord injury (SCI) is accompanied with several complications such as urinary tract deterioration, urinary incontinence, and consequently lower quality of life (QoL),significant morbidities, and occasionally death. Current therapeutic methods have some side effects and there is no treatment for the upper urinary tract injuries. Stem cell therapy is a promising method fortreating this condition. However, the best timing and the best route of its transplantation have not yet been determined. Animal models of SCI, especially in rats, are the most commonly used method for evaluatingthe efficacy of cell therapy in NGB improvement, and the most common assessment method is the urodynamic studies (UDS). However, there are variations in the range of UDS parameters among the published studies.The current review aimed to discuss the effect of stem cell transplantation on bladder dysfunction recovery based on urodynamic parameters after SCI in rats. For this purpose, the cell source, doses, the routeof administration, and the complete UDS equipment and its parameters were summarized in SCI models in rats. In some urodynamic test results, to some extent, an improvement in the lower urinary system functionwas observed in each treatment group. However, this improvement was far from full functional recovery. The average cell dose was about 1 million cells in every injected site. In most studies, the stem cells (SCs)were transplanted 9 days after the injury using PE-50 and PE-60. Many researchers have recommended further experimental and clinical studies to confirm this treatment modality.
机译：继发于脊髓损伤（SCI）的神经源性膀胱（NGB）伴有多种并发症，例如尿路恶化，尿失禁，从而降低生活质量（QoL），重大发病，偶尔死亡。当前的治疗方法具有一些副作用，并且没有针对上尿路损伤的治疗方法。干细胞疗法是一种有前途的治疗方法治疗这种情况。但是，尚未确定其最佳移植时机和最佳途径。 SCI的动物模型，尤其是在大鼠中，是最常用的评估方法细胞疗法对NGB改善的功效，最常见的评估方法是尿动力学研究（UDS）。但是，在已发表的研究中，UDS参数的范围存在差异。本综述旨在根据大鼠脊髓损伤后尿动力学参数探讨干细胞移植对膀胱功能障碍恢复的影响。为此，细胞来源，剂量，途径在大鼠的SCI模型中总结了完整的UDS设备及其参数。在一些尿动力学测试结果中，在一定程度上改善了下泌尿系统的功能在每个治疗组中观察到。但是，这种改进远没有完全恢复功能。每个注射部位的平均细胞剂量约为一百万个细胞。在大多数研究中，干细胞（SCs）受伤后第9天使用PE-50和PE-60进行移植。许多研究人员建议进行进一步的实验和临床研究，以确认这种治疗方式。

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