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Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent clinical magnetic resonance imaging for breast cancer imaging

机译:混合时域和连续波漫射光学层析成像仪同时进行临床磁共振成像可用于乳腺癌成像

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摘要

Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. The instrument is described in detail here. Image reconstructions of a tissue phantom are presented as an initial indicator of the system’s ability to accurately reconstruct optical properties and the concrete benefits of the spatial constraints provided by concurrent MRI. Last, we briefly discuss how various data combinations that the instrument could facilitate, including tissue perfusion, can enable more comprehensive assessment of lesion physiology.
机译:漫射光学层析成像技术已显示出在乳腺癌诊断和预后中的临床应用潜力,并且将其与其他结构成像方式结合使用可改善病变部位和功能组织特性的量化。在这里,我们介绍了一种混合扩散光学成像系统,该系统利用市售的MR表面线圈与成像套件中的磁共振成像(MRI)同时运行。该仪器可获取平行板几何形状中的连续波和时域漫射光学数据,从而可以绝对分配组织光学特性和三维层析成像。此外,该仪器还设计为结合扩散相关光谱测量技术来探测组织血流。此处详细介绍该仪器。组织体模的图像重建是该系统准确重建光学特性和同时进行MRI所提供的空间限制的具体好处的初步指标。最后,我们简要讨论了该仪器可促进的各种数据组合(包括组织灌注)如何使病变生理学更全面地评估。

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