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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Tc-99m TRODAT-1 SPECT Is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease
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Tc-99m TRODAT-1 SPECT Is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

机译：Tc-99m TRODAT-1 SPECT是终末期肾脏疾病患者不安腿综合征的潜在生物标志物

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Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SPECT was a biomarker for RLS but the correlation between the physiologic parameter was lacking. Methods: Overall, 32 patients were enrolled in the study and divided into the following 3 groups: (1) control ( = 13), (2) ESRD without RLS ( = 8) and (3) ESRD with RLS ( = 11). All patients had a clinical diagnosis of RLS and received Tc-99m TRODAT-1 SPECT. A subgroup analysis was performed to compare differences between the control and ESRD with RLS groups. Tc-99m TRODAT-1 SPECT was performed and activities in the striatum and occipital areas were measured using manually delineated regions of interest (ROIs) by an experienced nuclear medicine radiologist who was blinded to clinical data. Results: The total ratio of Tc-99m TRODAT SPECT was lower in the ESRD with RLS group ( = 0.046). The uptake ratio of TRODAT negatively correlated with serum parathyroid hormone ( = −0.577, = 0.015) and ferritin ( = −0.464, = 0.039) concentrations. However, the uptake positively correlated with the hemoglobin concentration ( = 0.531, = 0.011). The sensitivity and specificity of the total TRODAT ratio for predicting RLS in the overall population were 95.0% and 67.7%, respectively, at a cutoff value of 0.980 (area under the curve of receiver operating characteristic curve was 0.767, = 0.024). Conclusion: In patients with ESRD and RLS, Tc-99m TRODAT might be a potential biomarker. Dysregulated hemoglobin, serum parathyroid hormone and serum ferritin concentrations might influence the uptake of the TRODAT ratio.
机译：理由：不安腿综合征（RLS）是终末期肾脏疾病（ESRD）患者的常见并发症。但是，缺乏将尿毒症RLS与多巴胺能神经元联系在一起的生物标记。先前的研究表明Tc-99m TRODAT-1 SPECT是RLS的生物标志物，但缺乏生理参数之间的相关性。方法：共有32例患者入选该研究，分为以下3组：（1）对照（= 13），（2）无RLS的ESRD（= 8）和（3）有RLS的ESRD（= 11）。所有患者均具有RLS的临床诊断，并接受Tc-99m TRODAT-1 SPECT。进行亚组分析以比较对照组和ESRD组与RLS组之间的差异。进行了Tc-99m TRODAT-1 SPECT手术，并由经验丰富的核医学放射科医生使用人工划定的感兴趣区域（ROIs）测量纹状体和枕骨区域的活动，他对临床数据无知。结果：RLS组的ESRD中Tc-99m TRODAT SPECT的总比率较低（= 0.046）。 TRODAT的摄取率与血清甲状旁腺激素（= -0.577，= 0.015）和铁蛋白（= -0.464，= 0.039）浓度呈负相关。但是，摄取量与血红蛋白浓度呈正相关（= 0.531，= 0.011）。总TRODAT比值在总人群中预测RLS的敏感性和特异性分别为98.0％和67.7％，临界值为0.980（接收器工作特性曲线曲线下的面积为0.767，= 0.024）。结论：在ESRD和RLS患者中，Tc-99m TRODAT可能是潜在的生物标志物。血红蛋白失调，血清甲状旁腺激素和血清铁蛋白浓度可能会影响TRODAT比率的摄取。

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