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首页> 美国卫生研究院文献>Materials >Optimizing Manufacturing and Osseointegration of Ti6Al4V Implants through Precision Casting and Calcium and Phosphorus Ion Implantation? In Vivo Results of a Large-Scale Animal Trial
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Optimizing Manufacturing and Osseointegration of Ti6Al4V Implants through Precision Casting and Calcium and Phosphorus Ion Implantation? In Vivo Results of a Large-Scale Animal Trial

机译：通过精密铸造和钙磷离子注入优化Ti6Al4V植入物的制造和骨整合？大规模动物试验的体内结果

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Background: Uncemented implants are still associated with several major challenges, especially with regard to their manufacturing and their osseointegration. In this study, a novel manufacturing technique—an optimized form of precision casting—and a novel surface modification to promote osseointegration—calcium and phosphorus ion implantation into the implant surface—were tested in vivo. Methods: Cylindrical Ti6Al4V implants were inserted bilaterally into the tibia of 110 rats. We compared two generations of cast Ti6Al4V implants (CAST 1st GEN, n = 22, and CAST 2nd GEN, n = 22) as well as cast 2nd GEN Ti6Al4V implants with calcium (CAST + CA, n = 22) and phosphorus (CAST + P, n = 22) ion implantation to standard machined Ti6Al4V implants (control, n = 22). After 4 and 12 weeks, maximal pull-out force and bone-to-implant contact rate (BIC) were measured and compared between all five groups. Results: There was no significant difference between all five groups after 4 weeks or 12 weeks with regard to pull-out force ( > 0.05, Kruskal Wallis test). Histomorphometric analysis showed no significant difference of BIC after 4 weeks ( > 0.05, Kruskal–Wallis test), whereas there was a trend towards a higher BIC in the CAST + P group (54.8% ± 15.2%), especially compared to the control group (38.6% ± 12.8%) after 12 weeks ( = 0.053, Kruskal–Wallis test). Conclusion: In this study, we found no indication of inferiority of Ti6Al4V implants cast with the optimized centrifugal precision casting technique of the second generation compared to standard Ti6Al4V implants. As the employed manufacturing process holds considerable economic potential, mainly due to a significantly decreased material demand per implant by casting near net-shape instead of milling away most of the starting ingot, its application in manufacturing uncemented implants seems promising. However, no significant advantages of calcium or phosphorus ion implantation could be observed in this study. Due to the promising results of ion implantation in previous in vitro and in vivo studies, further in vivo studies with different ion implantation conditions should be considered.
机译：背景：未胶合的植入物仍然面临若干重大挑战，尤其是在制造和骨整合方面。在这项研究中，在体内测试了一种新颖的制造技术-一种精确铸造的优化形式-以及一种新颖的表面改性以促进骨整合-将钙和磷离子植入植入物表面。方法：将圆柱形Ti6Al4V植入物双边插入110只大鼠的胫骨中。我们比较了两代铸造的Ti6Al4V植入物（CAST 1st GEN，n = 22和CAST 2nd GEN，n = 22）以及铸造的第二代Ti6Al4V植入物的钙（CAST + CA，n = 22）和磷（CAST + P，n = 22）离子注入到标准机加工的Ti6Al4V注入中（对照，n = 22）。在第4周和第12周后，对所有五个组的最大拔出力和骨与植入物的接触率（BIC）进行了测量和比较。结果：4周或12周后，五组之间的拔出力无显着差异（> 0.05，Kruskal Wallis测试）。组织形态计量学分析显示4周后BIC没有显着差异（> 0.05，Kruskal–Wallis检验），而CAST + P组的BIC有升高的趋势（54.8％±15.2％），特别是与对照组相比12周后（38.6％±12.8％）（= 0.053，Kruskal–Wallis检验）。结论：在这项研究中，我们没有发现使用第二代优化离心精密铸造技术铸造的Ti6Al4V植入物与标准Ti6Al4V植入物相比劣质的迹象。由于所采用的制造工艺具有可观的经济潜力，这主要是由于通过铸造近净形而不是铣削掉大部分起始铸锭来显着降低每个植入物的材料需求，其在制造非骨水泥植入物中的应用似乎很有希望。然而，在这项研究中没有观察到钙或磷离子植入的显着优势。由于在先前的体外和体内研究中离子注入的有希望的结果，应考虑在不同离子注入条件下进行进一步的体内研究。

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