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首页> 美国卫生研究院文献>Micromachines >A Miniature Fibre-Optic Raman Probe Fabricated by Ultrafast Laser-Assisted Etching
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A Miniature Fibre-Optic Raman Probe Fabricated by Ultrafast Laser-Assisted Etching

机译：超快激光辅助刻蚀制造的光纤拉曼探针

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摘要

Optical biopsy describes a range of medical procedures in which light is used to investigate disease in the body, often in hard-to-reach regions via optical fibres. Optical biopsies can reveal a multitude of diagnostic information to aid therapeutic diagnosis and treatment with higher specificity and shorter delay than traditional surgical techniques. One specific type of optical biopsy relies on Raman spectroscopy to differentiate tissue types at the molecular level and has been used successfully to stage cancer. However, complex micro-optical systems are usually needed at the distal end to optimise the signal-to-noise properties of the Raman signal collected. Manufacturing these devices, particularly in a way suitable for large scale adoption, remains a critical challenge. In this paper, we describe a novel fibre-fed micro-optic system designed for efficient signal delivery and collection during a Raman spectroscopy-based optical biopsy. Crucially, we fabricate the device using a direct-laser-writing technique known as ultrafast laser-assisted etching which is scalable and allows components to be aligned passively. The Raman probe has a sub-millimetre diameter and offers confocal signal collection with 71.3% ± 1.5% collection efficiency over a 0.8 numerical aperture. Proof of concept spectral measurements were performed on mouse intestinal tissue and compared with results obtained using a commercial Raman microscope.
机译：光学活检描述了一系列医疗程序，在这些程序中，通常通过光纤将光线用于研究人体疾病，通常是在难以触及的区域。光学活检可以揭示许多诊断信息，以比传统手术技术更高的特异性和更短的延迟来辅助治疗性诊断和治疗。一种特定类型的光学活检依靠拉曼光谱在分子水平上区分组织类型，并已成功用于癌症分期。然而，通常需要在远端使用复杂的微光学系统来优化所收集的拉曼信号的信噪比特性。制造这些设备，尤其是以适合大规模采用的方式制造，仍然是一个严峻的挑战。在本文中，我们描述了一种新颖的光纤馈送微光学系统，该系统设计用于在基于拉曼光谱的光学活检过程中进行有效的信号传递和收集。至关重要的是，我们使用称为超快激光辅助蚀刻的直接激光写入技术制造该设备，该技术具有可扩展性并允许组件被动对齐。拉曼探头的直径小于1毫米，可在0.8数值孔径上以71.3％±1.5％的采集效率提供共聚焦信号采集。在小鼠肠组织上进行了概念光谱测量，并与使用市售拉曼显微镜获得的结果进行了比较。

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