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首页> 美国卫生研究院文献>Molecules >Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate
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Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate

机译：跨血浆膜的脂质体药物递送系统：内皮细胞之间的距离和血流速度的作用

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摘要

This paper discusses specific features of the interactions of small-diameter liposomes with the cytoplasmic membrane of endothelial cells using in silico methods. The movement pattern of the liposomal drug delivery system was modeled in accordance with the conditions of the near-wall layer of blood flow. Our simulation results show that the liposomes can become stuck in the intercellular gaps and even break down when the gap is reduced. Liposomes stuck in the gaps are capable of withstanding a shell deformation of ~15% with an increase in liposome energy by 26%. Critical deformation of the membrane gives an impetus to drug release from the liposome outward. We found that the liposomes moving in the near-wall layer of blood flow inevitably stick to the membrane. Liposome sticking on the membrane is accompanied by its gradual splicing with the membrane bilayer. This leads to a gradual drug release inside the cell.
机译：本文采用计算机方法探讨了小直径脂质体与内皮细胞胞质膜相互作用的具体特征。脂质体药物输送系统的运动模式是根据血流近壁层的情况建模的。我们的模拟结果表明，脂质体可能会卡在细胞间的间隙中，甚至在间隙减小时会破裂。卡在缝隙中的脂质体能够承受〜15％的壳形变形，脂质体能量增加26％。膜的严重变形促进了药物从脂质体向外释放。我们发现，在血流近壁层中移动的脂质体不可避免地粘附在膜上。脂质体粘附在膜上的同时伴随着膜双层的逐渐剪接。这导致药物在细胞内逐渐释放。

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