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Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil

机译：樟树叶片精油的抑菌和抑菌抑制活性研究

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摘要

Many essential oils (EOs) regulate the quorum-sensing (QS) system of pathogens and inhibit the virulence expression. Interference with QS can potentially reduce bacterial multidrug resistance and aid the biological control of bacterial disease. In the present work, the antibacterial and anti-QS activities of leaf EO were investigated. A total of 23 chemical components with relative levels ≥0.11%, including a large number of terpene compounds, were identified in leaf EO by gas chromatography–mass spectrometry (GC-MS). The principal component was linalool, followed by eucalyptol, with relative levels of 51.57% and 22.07%, respectively. The minimum inhibitory concentration (MIC) and antibacterial activity of EO were examined, and and ATCC25922 showed the highest and lowest sensitivity to EO, respectively. Tests of QS inhibitory activity revealed that EO significantly decreased the production of violacein and biofilm biomass in , with the maximum inhibition rates of 63% and 77.64%, respectively, and inhibited the biofilm formation and swarming movement, independent of affecting the growth of . Addition of EO also resulted in downregulation of the expression of the acyl-homoserine lactones (AHL) synthesis gene ( ) and transcription regulator ( ), and inhibited the expression of QS-regulated virulence genes, including , , , , , , , and . Collectively, the prominent antibacterial activity and anti-QS activities clearly support that EO acts as a potential antibacterial agent and QS inhibitor in the prevention of bacterial contamination.
机译：许多精油（EO）调节病原体的群体感应（QS）系统并抑制毒力表达。干扰QS可能会降低细菌的多药耐药性，并有助于细菌疾病的生物防治。在目前的工作中，研究了叶EO的抗菌和抗QS活性。通过气相色谱-质谱法（GC-MS）在叶片EO中共鉴定出23种相对含量≥0.11％的化学成分，其中包括大量的萜烯化合物。主要成分是芳樟醇，其次是桉油精，相对含量分别为51.57％和22.07％。检查了EO的最低抑菌浓度（MIC）和抗菌活性，并且ATCC25922对EO的敏感性最高。 QS抑制活性的测试表明，EO显着降低了其中的紫胶素和生物膜生物量的产生，最大抑制率分别为63％和77.64％，并抑制了生物膜的形成和虫群运动，而与影响其生长无关。 EO的添加还导致酰基高丝氨酸内酯（AHL）合成基因（）和转录调节剂（）的表达下调，并抑制QS调节的毒力基因的表达，包括，，，，，和。总的来说，突出的抗菌活性和抗QS活性明确支持EO在预防细菌污染方面可作为潜在的抗菌剂和QS抑制剂。

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