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首页> 美国卫生研究院文献>Molecular Medicine >Neonatal hair profiling reveals a metabolic phenotype of monochorionic twins with selective intrauterine growth restriction and abnormal umbilical artery flow
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Neonatal hair profiling reveals a metabolic phenotype of monochorionic twins with selective intrauterine growth restriction and abnormal umbilical artery flow

机译：新生儿的头发轮廓显示单绒毛膜双胞胎的代谢表型具有选择性的宫内生长受限和脐动脉血流异常

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Classifications of type 1, type 2, and type 3 selective intrauterine growth restriction (T1& T2&T3 sIUGR) in monochorionic twins via placental sharing, velamentous cord insertion, anastomoses, and umbilical artery flow. The white dotted lines connect the smallest diameter vascular anastomoses points on the surface of the chorionic plate and divide the placenta into larger and smaller twin portions. The red regions in the , , and indicate that the blood flow of umbilical artery directs toward the ultrasound probe. The blue regions in the , show that the direction of blood flow in the umbilical artery is opposite to the ultrasound probe. T1 sIUGR placenta - placenta was infused with placental vascular dye injection. This displays unequal placental sharing and discordance cord insertion as the features of sIUGR placenta, but vascular anastomoses remain similar to uncomplicated monochorionic twins. T2 sIUGR placenta - large arterioarterial anastomoses (2 ≥ mm, yellow circle) are present in 18% of placenta. T3 sIUGR placenta large arterioarterial anastomoses (≥2 mm, yellow circle) are present in 98% of placenta. In T1 sIUGR, the umbilical artery Doppler waveform has positive end-diastolic velocity in the umbilical artery. In T2 sIUGR, there is absent or reversed end-diastolic flow (AREDF) in the umbilical artery. In T3 sIGUR, there is a cyclical or intermittent pattern of AREDF in the umbilical artery
机译：通过胎盘共享，软膜插入，吻合和脐动脉血流在单绒毛膜双胎中对1型，2型和3型选择性子宫内生长限制（T1＆T2＆T3 sIUGR）进行分类。白色虚线连接绒毛膜板表面上直径最小的血管吻合点，并将胎盘分为较大和较小的双胞胎部分。 ，和中的红色区域表示脐动脉​​的血流朝向超声探头。的蓝色区域表示脐动脉​​中的血流方向与超声探头相反。 T1 sIUGR胎盘-胎盘注入胎盘血管染料注射液。这显示不平等的胎盘共享和不一致的脐带插入是sIUGR胎盘的特征，但血管吻合仍然与简单的单绒毛膜双胎相似。 T2 sIUGR胎盘-18％的胎盘中出现大动脉吻合（2≥mm，黄色圆圈）。 98％的胎盘中存在T3 sIUGR胎盘大动脉吻合（≥2mm，黄色圆圈）。在T1 sIUGR中，脐动脉多普勒波形在脐动脉中舒张末期速度为正。在T2 sIUGR中，脐动脉中舒张末期血流（AREDF）缺失或逆转。在T3 sIGUR中，脐动脉中存在AREDF的周期性或间歇性模式

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