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首页> 美国卫生研究院文献>Oncotarget >Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats
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Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats

机译：松果体可预防化学诱导的口腔癌发生并抑制大鼠的肿瘤进展

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摘要

Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. Rats submitted to sham surgery were used as control. Pinealectomy promoted an increase of 140% in OSCC occurrence when compared to sham animals. Tumors from pinealectomized rats displayed a higher volume and thickness than the tumors from sham-operated animals. Pinealectomy induced atrophy of the epithelium adjacent to the oral lesions. Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. In addition, nuclear overexpression of ERK1/2 and p53 was also observed in the front of carcinomas from pinealectomized rats. These results reveal that pineal gland plays a protective role against oral carcinogenesis. The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation.
机译：临床研究表明，褪黑激素的抑制和昼夜节律障碍可能与轮班工人的癌症发展有关。研究还表明，在临床前模型中，松果体切除术后抑制褪黑激素会增加癌症的发病率。但是，没有研究评估松果体切除术对口腔癌发展的影响。在当前的研究中，我们调查了松果体切除术对大鼠口腔鳞状细胞癌（OSCC）发生和发展的影响。接受假手术的大鼠用作对照。与假手术动物相比，松果切除术可促进OSCC发生率增加140％。松果体切除大鼠的肿瘤比假手术动物的肿瘤具有更高的体积和厚度。松果体切除术导致邻近口腔病变的上皮萎缩。松果体切除的大鼠在OSCC的浸润前部显示出更高的肿瘤相关巨噬细胞和嗜酸性粒细胞平均数。此外，在松果体切除大鼠的癌前部还观察到了ERK1 / 2和p53的核过表达。这些结果表明，松果体对口腔癌变起着保护作用。松果体切除术引起的褪黑激素抑制可能通过作用于ERK1 / 2和p53途径并调节肿瘤炎症而促进口腔癌的发展。

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