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首页> 美国卫生研究院文献>Nutrients >Multi-Micronutrient Fortified Rice Improved Serum Zinc and Folate Concentrations of Cambodian School Children. A Double-Blinded Cluster-Randomized Controlled Trial
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Multi-Micronutrient Fortified Rice Improved Serum Zinc and Folate Concentrations of Cambodian School Children. A Double-Blinded Cluster-Randomized Controlled Trial

机译：多微量营养素强化稻米改善了柬埔寨学童的血清锌和叶酸浓度。双盲聚类随机对照试验

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Background: Within Cambodia, micronutrient deficiencies continue to be prevalent in vulnerable groups, such as women and children. Fortification of staple foods such as rice could be a promising strategy for Cambodia to improve micronutrient status. Objective: Our objective was to investigate the impact of multiple-micronutrient fortified rice (MMFR), distributed through a World Food Program school-meals program (WFP-SMP) on serum zinc concentrations and folate status in a double-blind, cluster-randomized, placebo-controlled trial. Methods: Sixteen schools were randomly assigned to receive one of three different types of extruded-fortified rice (UltraRice Original (URO), UltraRice New (URN), or NutriRice) or unfortified rice (placebo) six days a week for six months. A total of 1950 schoolchildren (6–16 years old) participated in the study. Serum zinc (all groups) and folate (only in NutriRice and placebo group) concentrations were assessed from morning non-fasting antecubital blood samples and were measured at three time points (baseline and after three and six months). Results: After six months of intervention, serum zinc concentrations were significantly increased in all fortified rice group compared to placebo and baseline (0.98, 0.85 and 1.40 µmol/L for URO, URN and NutriRice, respectively) (interaction effect: < 0.001 for all). Children in the intervention groups had a risk of zinc deficiencies of around one third (0.35, 039, and 0.28 for URO, URN, and NutriRice, respectively) compared to the placebo ( < 0.001 for all). The children receiving NutriRice had higher serum folate concentrations at endline compared to children receiving normal rice (+2.25 ng/mL, = 0.007). Conclusions: This study showed that the high prevalence of zinc and folate deficiency in Cambodia can be improved through the provision of MMFR. As rice is the staple diet for Cambodia, MMFR should be considered to be included in the school meal program and possibilities should be explored to introduce MMFR to the general population.
机译：背景：在柬埔寨，微量营养素缺乏症在诸如妇女和儿童等脆弱群体中仍然普遍存在。大米等主食的强化可能是柬埔寨改善微量营养素状况的有希望的战略。目的：我们的目的是研究通过世界粮食计划署的学校供餐计划（WFP-SMP）分配的多种微量营养素强化大米（MMFR）对双盲，整群随机分配的血清锌浓度和叶酸状态的影响，安慰剂对照试验。方法：随机分配16所学校，每星期六天接受三种不同类型的膨化强化米（UltraRice Original（URO），UltraRice New（URN）或NutriRice）或非强化米（安慰剂）中的一种。共有1950名小学生（6至16岁）参加了这项研究。从早晨非禁食前肘关节血液样本中评估血清锌（所有组）和叶酸（仅在NutriRice和安慰剂组中）的浓度，并在三个时间点（基线以及三个，六个月后）进行测量。结果：干预六个月后，所有强化大米组的血清锌浓度均较安慰剂和基线水平显着升高（URO，URN和NutriRice分别为0.98、0.85和1.40 µmol / L）（相互作用：<0.001 ）。与安慰剂相比，干预组的儿童锌缺乏风险约为三分之一（分别为URO，URN和NutriRice，分别为0.35、039和0.28）（所有<0.001）。与接受正常大米的儿童相比，接受NutriRice的儿童终末血清叶酸浓度更高（+2.25 ng / mL，= 0.007）。结论：这项研究表明，通过提供MMFR可以改善柬埔寨锌和叶酸缺乏的高患病率。由于大米是柬埔寨的主要饮食，因此应考虑将MMFR纳入学校膳食计划，并应探索将MMFR引入普通人群的可能性。

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