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首页> 美国卫生研究院文献>Polymers >Bi-layered Nanofibers Membrane Loaded with Titanium Oxide and Tetracycline as Controlled Drug Delivery System for Wound Dressing Applications
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Bi-layered Nanofibers Membrane Loaded with Titanium Oxide and Tetracycline as Controlled Drug Delivery System for Wound Dressing Applications

机译：载有氧化钛和四环素的双层纳米纤维膜作为伤口敷料应用中的可控药物输送系统

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The aim of this study is to develop a novel functional bi-layered membrane loaded titanium oxide (TiO ) and tetracycline (TTC) for application in wound dressing. The advantages of the electrospinning technique have to be considered for the uniform distribution of nanoparticles and TTC drug. The as prepared nanofibers and TiO were characterized in terms of morphology, fiber diameter, mechanical properties and surface wettability. The in vitro drug release study revealed initial burst release followed by a sustained control release of TTC for 4 days. The in vitro antibacterial of the bi-layered nanofibers was conducted against Gram-positive ( ) and Gram-negative ( ) bacteria species showing excellent antibacterial effect for drug loaded samples compared with PCL nanofibers. Subsequently, cell counting kit-8 (CCK-8) and confocal laser scanning microscopy (CLSM) were used to evaluate its biocompatibility in vitro. Our results revealed that the bi-layered membrane has better antibacterial and cell compatibility than the control fiber. This suggests that the fabricated biocompatible scaffold is appropriate for a variety of wound dressing applications.
机译：这项研究的目的是开发一种新型的功能性双层膜负载氧化钛（TiO）和四环素（TTC），用于伤口敷料中。必须考虑静电纺丝技术的优点，才能使纳米颗粒和TTC药物均匀分布。所制备的纳米纤维和TiO的形态，纤维直径，机械性能和表面润湿性均得到了表征。体外药物释放研究表明，最初的突释释放是TTC的持续控制释放，持续4天。双层纳米纤维的体外抗菌作用是针对革兰氏阳性和革兰氏阴性细菌，与PCL纳米纤维相比，对载药样品显示出优异的抗菌效果。随后，使用细胞计数试剂盒8（CCK-8）和共聚焦激光扫描显微镜（CLSM）评估其体外生物相容性。我们的结果表明，该双层膜比对照纤维具有更好的抗菌和细胞相容性。这表明所制造的生物相容性支架适用于各种伤口敷料应用。

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